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EVALUATION OF CIRCUMSPOROZOITE PROTEIN OF Plasmodium vivax TO ESTIMATE ITS PREVALENCE IN OIAPOQUE , AMAPÁ STATE, BRAZIL, BORDERING FRENCH GUIANA

Overview of attention for article published in Revista do Instituto de Medicina Tropical de São Paulo, January 2016
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Title
EVALUATION OF CIRCUMSPOROZOITE PROTEIN OF Plasmodium vivax TO ESTIMATE ITS PREVALENCE IN OIAPOQUE , AMAPÁ STATE, BRAZIL, BORDERING FRENCH GUIANA
Published in
Revista do Instituto de Medicina Tropical de São Paulo, January 2016
DOI 10.1590/s1678-9946201658072
Pubmed ID
Authors

Margarete do Socorro Mendonça GOMES, José Luiz Fernandes VIEIRA, Gustavo Capatti CASSIANO, Lise MUSSET, Eric LEGRAND, Mathieu NACHER, Vanja Suely Calvosa D'Almeida COUTO, Ricardo Luiz Dantas MACHADO, Álvaro Augusto Ribeiro D'Almeida COUTO

Abstract

Malaria is a major health problem for people who live on the border between Brazil and French Guiana. Here we discuss Plasmodium vivax distribution pattern in the town of Oiapoque, Amapá State using the circumsporozoite (CS) gene as a marker. Ninety-one peripheral blood samples from P. vivax patients have been studied. Of these, 64 individuals were from the municipality of Oiapoque (Amapá State, Brazil) and 27 patients from French Guiana (August to December 2011). DNA extraction was performed, and a fragment of the P. vivax CS gene was subsequently analyzed using PCR/RFLP. The VK210 genotype was the most common in both countries (48.36% in Brazil and 14.28% in French Guiana), followed by the P. vivax-like (1.10% in both Brazil and French Guiana) and VK247 (1.10% only in Brazil) in single infections. We were able to detect all three CS genotypes simultaneously in mixed infections. There were no statistically significant differences either regarding infection site or parasitaemia among individuals with different genotypes. These results suggest that the same genotypes circulating in French Guiana are found in the municipality of Oiapoque in Brazil. These findings suggest that there may be a dispersion of parasitic populations occurring between the two countries. Most likely, this distribution is associated with prolonged and/or more complex transmission patterns of these genotypes in Brazil, bordering French Guiana.

Mendeley readers

The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 14 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 3 21%
Student > Master 3 21%
Researcher 2 14%
Other 1 7%
Student > Bachelor 1 7%
Other 0 0%
Unknown 4 29%
Readers by discipline Count As %
Medicine and Dentistry 2 14%
Biochemistry, Genetics and Molecular Biology 2 14%
Immunology and Microbiology 2 14%
Pharmacology, Toxicology and Pharmaceutical Science 1 7%
Agricultural and Biological Sciences 1 7%
Other 0 0%
Unknown 6 43%