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High serum levels of 8-OHdG are an independent predictor of post-stroke depression in Chinese stroke survivors

Overview of attention for article published in Neuropsychiatric Disease and Treatment, February 2018
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Title
High serum levels of 8-OHdG are an independent predictor of post-stroke depression in Chinese stroke survivors
Published in
Neuropsychiatric Disease and Treatment, February 2018
DOI 10.2147/ndt.s155144
Pubmed ID
Authors

Zhihua Liu, Yan Cai, Jincai He

Abstract

Although previous studies have investigated oxidative stress biomarkers in association with depression in non-stroke subjects, the association between oxidative deoxyribonucleic acid damage and post-stroke depression (PSD) remains unelucidated. Two hundred forty-one first-ever ischemic stroke patients were consecutively recruited within the first 24 h of stroke onset and were followed up at 1 month. Serum 8-hydroxy-2'-deoxyguanosine (8-OHdG) and catalase (CAT) levels were measured within 24 h of admission using a commercially available enzyme-linked immunosorbent assay. The 17-item Hamilton Depression Scale was used to evaluate depressive symptoms. Diagnosis of PSD was made in line with theDiagnostic and Statistical Manual of Mental Disorders, 4th edition criteria for depression. Serum levels of 8-OHdG (P<0.001) and CAT (P=0.025) increased in depressed patients at admission. A positive correlation was found between the 8-OHdG and CAT levels in both the total stroke patients (r=0.320,P<0.001) and the depressed patients (r=0.300,P=0.012). The 8-OHdG levels were positively correlated with the 17-item Hamilton Depression Scale scores (r=0.129,P=0.046) in depressed patients. Multivariate analyses found that 8-OHdG levels ≥200.0 ng/L were independently associated with PSD (odds ratio, 7.477; 95% CI, 3.342-16.289,P<0.001) after adjusting for possible relevant confounders. Higher serum 8-OHdG levels at admission were found to be correlated with PSD 1 month after stroke.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 25 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 3 12%
Student > Ph. D. Student 3 12%
Student > Doctoral Student 3 12%
Student > Postgraduate 2 8%
Student > Master 2 8%
Other 4 16%
Unknown 8 32%
Readers by discipline Count As %
Psychology 3 12%
Medicine and Dentistry 3 12%
Neuroscience 2 8%
Agricultural and Biological Sciences 1 4%
Sports and Recreations 1 4%
Other 3 12%
Unknown 12 48%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 February 2018.
All research outputs
#8,379,801
of 14,537,474 outputs
Outputs from Neuropsychiatric Disease and Treatment
#1,214
of 2,487 outputs
Outputs of similar age
#141,492
of 274,801 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#36
of 80 outputs
Altmetric has tracked 14,537,474 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,487 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one is in the 45th percentile – i.e., 45% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 274,801 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 80 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.