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Long-term use of valproic acid and the prevalence of cancers in bipolar disorder patients in a Taiwanese population: An association analysis using the National Health Insurance Research Database (NHIRD…

Overview of attention for article published in Journal of Affective Disorders, May 2018
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Mentioned by

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3 tweeters
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1 Facebook page

Citations

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1 Dimensions

Readers on

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15 Mendeley
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Title
Long-term use of valproic acid and the prevalence of cancers in bipolar disorder patients in a Taiwanese population: An association analysis using the National Health Insurance Research Database (NHIRD)
Published in
Journal of Affective Disorders, May 2018
DOI 10.1016/j.jad.2018.02.047
Pubmed ID
Authors

Cheng Chia Lin, Tsung-Cheng Hsieh, Lawrence Shih-Hsin Wu

Abstract

Epigenetic events play a major role in the carcinogenesis of many cancers. A retrospective cohort study had been performed to evaluate the effects of exposure to the anticonvulsant agent valproic acid (VPA), a histone deacetylase inhibitor, on the risk of developing cancers. The study was based on the 1998 through 2009 National Health Insurance Research Database (NHIRD), provided by the Taiwan National Health Research Institute. Patients with a diagnosis of bipolar disorder (ICD-9-CM codes 296.0, 296.1, 296.4-8) from 1998 to 2009 were identified. VPA and lithium were the primary index drugs. Patients treated with anticonvulsants who did not use VPA or lithium were selected as the control group. Competing risk regression analysis were used to estimate hazards ratios (HR) and 95% confidence intervals (95% CI) reflecting the association between use of VPA and cancer incidence. The cancer incidence of bipolar disorder patients treated with VPA was no significant difference than treated with lithium and other anticonvulsants. In subgroup analysis, VPA associated to higher risk of genitourinary cancer in the duration < 1 year group (HR: 3.49; 95%CI: 1.04, 11.67). No significant differences in other cancers incidence in any duration of VPA treatment. The cancer prevalence in selected bipolar disorder patients was still low. The sample size was not enough for some types of cancer. A role of VPA in cancer prevention was not found in this study. An increased subgroup risk of genitourinary cancer was observed.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 15 100%

Demographic breakdown

Readers by professional status Count As %
Other 6 40%
Unspecified 2 13%
Student > Ph. D. Student 2 13%
Student > Postgraduate 1 7%
Student > Bachelor 1 7%
Other 3 20%
Readers by discipline Count As %
Unspecified 5 33%
Medicine and Dentistry 3 20%
Psychology 2 13%
Social Sciences 2 13%
Sports and Recreations 1 7%
Other 2 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 March 2018.
All research outputs
#8,616,970
of 13,734,629 outputs
Outputs from Journal of Affective Disorders
#3,985
of 6,186 outputs
Outputs of similar age
#161,355
of 270,391 outputs
Outputs of similar age from Journal of Affective Disorders
#137
of 242 outputs
Altmetric has tracked 13,734,629 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,186 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.2. This one is in the 27th percentile – i.e., 27% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 270,391 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 242 others from the same source and published within six weeks on either side of this one. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.