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In vitro activity of ivermectin against Staphylococcus aureus clinical isolates

Overview of attention for article published in Antimicrobial Resistance & Infection Control, February 2018
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (94th percentile)
  • High Attention Score compared to outputs of the same age and source (91st percentile)

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69 X users
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1 YouTube creator

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Title
In vitro activity of ivermectin against Staphylococcus aureus clinical isolates
Published in
Antimicrobial Resistance & Infection Control, February 2018
DOI 10.1186/s13756-018-0314-4
Pubmed ID
Authors

Shoaib Ashraf, Umer Chaudhry, Ali Raza, Debasri Ghosh, Xin Zhao

Abstract

Ivermectin is an endectocide against many parasites. Though being a macrocyclic lactone, its activity against bacteria has been less known, possibly due to the fact that micromolar concentrations at tissue levels are required to achieve a therapeutic effect. Among pathogenic bacteria of major medical significance,Staphylococcus aureuscause a number of diseases in a wide variety of hosts including humans and animals. It has been attributed as one of the most pathogenic organisms. The emergence of methicillin resistance has made the treatment ofS. aureuseven more difficult as it is now resistant to most of the available antibiotics. Thus, search for alternate anti-staphylococcal agents requires immediate attention. Twenty-one clinical isolates ofS. aureuswere isolated from bovine milk collected from Lahore and Faisalabad Pakistan. Different anthelmintics including levamisole, albendazole and ivermectin were tested againstS. aureusto determine their minimum inhibitory concentrations. This was followed-up by growth curve analysis, spot assay and time-kill kinetics. The results showed that ivermectin but not levamisole or albendazole exhibited a potent anti-staphylococcal activity at the concentrations of 6.25 and 12.5 μg/ml against two isolates. Interestingly, one of the isolate was sensitive while the other was resistant to methicillin/cefoxitin. Our novel findings indicate that ivermectin has an anti-bacterial effect against certainS.aureusisolates. However, to comprehend why ivermectin did not inhibit the growth of all Staphylococci needs further investigation. Nevertheless, we have extended the broad range of known pharmacological effects of ivermectin. As pharmacology and toxicology of ivermectin are well known, its further development as an anti-staphylococcal agent is potentially appealing.

X Demographics

X Demographics

The data shown below were collected from the profiles of 69 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 98 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 98 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 14 14%
Student > Bachelor 10 10%
Student > Postgraduate 5 5%
Student > Master 5 5%
Other 4 4%
Other 13 13%
Unknown 47 48%
Readers by discipline Count As %
Medicine and Dentistry 13 13%
Biochemistry, Genetics and Molecular Biology 7 7%
Pharmacology, Toxicology and Pharmaceutical Science 7 7%
Veterinary Science and Veterinary Medicine 5 5%
Immunology and Microbiology 5 5%
Other 18 18%
Unknown 43 44%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 48. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 March 2024.
All research outputs
#879,552
of 25,593,129 outputs
Outputs from Antimicrobial Resistance & Infection Control
#73
of 1,469 outputs
Outputs of similar age
#19,702
of 344,895 outputs
Outputs of similar age from Antimicrobial Resistance & Infection Control
#5
of 48 outputs
Altmetric has tracked 25,593,129 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,469 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.2. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 344,895 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 48 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.