Title |
Letter to the editor: blood processing and sample storage have negligible effects on methylation
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Published in |
Clinical Epigenetics, February 2018
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DOI | 10.1186/s13148-018-0455-6 |
Pubmed ID | |
Authors |
Kira Groen, Rodney A. Lea, Vicki E. Maltby, Rodney J. Scott, Jeannette Lechner-Scott |
Abstract |
DNA methylation is a dynamic epigenetic mechanism. Researchers aiming to assess archived DNA samples are expressing concern about the effect of technical factors on methylation, as this may confound results. We reviewed recent reports examining this issue in blood samples and concluded that variation in collection, storage, and processing of blood DNA confers negligible effects on both global methylation and methylation status of specific genes. These results are concordant with studies that have investigated the effect of sample storage and processing on methylation in other tissues, such as tumour, sperm, and placenta samples. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 33% |
Spain | 1 | 17% |
Unknown | 3 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 6 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 62 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 19 | 31% |
Researcher | 16 | 26% |
Student > Master | 7 | 11% |
Student > Bachelor | 4 | 6% |
Professor > Associate Professor | 3 | 5% |
Other | 6 | 10% |
Unknown | 7 | 11% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 19 | 31% |
Agricultural and Biological Sciences | 13 | 21% |
Medicine and Dentistry | 8 | 13% |
Nursing and Health Professions | 2 | 3% |
Neuroscience | 2 | 3% |
Other | 6 | 10% |
Unknown | 12 | 19% |