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Letter to the editor: blood processing and sample storage have negligible effects on methylation

Overview of attention for article published in Clinical Epigenetics, February 2018
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  • Above-average Attention Score compared to outputs of the same age (54th percentile)
  • Average Attention Score compared to outputs of the same age and source

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Title
Letter to the editor: blood processing and sample storage have negligible effects on methylation
Published in
Clinical Epigenetics, February 2018
DOI 10.1186/s13148-018-0455-6
Pubmed ID
Authors

Kira Groen, Rodney A. Lea, Vicki E. Maltby, Rodney J. Scott, Jeannette Lechner-Scott

Abstract

DNA methylation is a dynamic epigenetic mechanism. Researchers aiming to assess archived DNA samples are expressing concern about the effect of technical factors on methylation, as this may confound results. We reviewed recent reports examining this issue in blood samples and concluded that variation in collection, storage, and processing of blood DNA confers negligible effects on both global methylation and methylation status of specific genes. These results are concordant with studies that have investigated the effect of sample storage and processing on methylation in other tissues, such as tumour, sperm, and placenta samples.

X Demographics

X Demographics

The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 62 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 19 31%
Researcher 16 26%
Student > Master 7 11%
Student > Bachelor 4 6%
Professor > Associate Professor 3 5%
Other 6 10%
Unknown 7 11%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 19 31%
Agricultural and Biological Sciences 13 21%
Medicine and Dentistry 8 13%
Nursing and Health Professions 2 3%
Neuroscience 2 3%
Other 6 10%
Unknown 12 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 March 2018.
All research outputs
#7,546,261
of 23,023,224 outputs
Outputs from Clinical Epigenetics
#559
of 1,265 outputs
Outputs of similar age
#159,039
of 446,267 outputs
Outputs of similar age from Clinical Epigenetics
#18
of 33 outputs
Altmetric has tracked 23,023,224 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,265 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.5. This one has gotten more attention than average, scoring higher than 53% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 446,267 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.
We're also able to compare this research output to 33 others from the same source and published within six weeks on either side of this one. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.