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A Novel Mammalian Iron-regulated Protein Involved in Intracellular Iron Metabolism

Overview of attention for article published in Journal of Biological Chemistry, March 2000
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (89th percentile)
  • High Attention Score compared to outputs of the same age and source (94th percentile)

Mentioned by

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15 patents
wikipedia
1 Wikipedia page

Citations

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939 Dimensions

Readers on

mendeley
190 Mendeley
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1 CiteULike
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Title
A Novel Mammalian Iron-regulated Protein Involved in Intracellular Iron Metabolism
Published in
Journal of Biological Chemistry, March 2000
DOI 10.1074/jbc.m000713200
Pubmed ID
Authors

Sherry Abboud, David J. Haile

Abstract

We have isolated and characterized a novel iron-regulated gene that is homologous to the divalent metal transporter 1 family of metal transporters. This gene, termed metal transporter protein (mtp1), is expressed in tissues involved in body iron homeostasis including the developing and mature reticuloendothelial system, the duodenum, and the pregnant uterus. MTP1 is also expressed in muscle and central nervous system cells in the embryo. At the subcellular level, MTP1 is localized to the basolateral membrane of the duodenal epithelial cell and a cytoplasmic compartment of reticuloendothelial system cells. Overexpression of MTP1 in tissue culture cells results in intracellular iron depletion. In the adult mouse, MTP1 expression in the liver and duodenum are reciprocally regulated. Iron deficiency induces MTP1 expression in the duodenum but down-regulates expression in the liver. These data indicate that MTP1 is an iron-regulated membrane-spanning protein that is involved in intracellular iron metabolism.

Mendeley readers

The data shown below were compiled from readership statistics for 190 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 <1%
Czechia 1 <1%
Italy 1 <1%
Korea, Republic of 1 <1%
Unknown 186 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 40 21%
Researcher 32 17%
Student > Master 32 17%
Student > Bachelor 20 11%
Student > Doctoral Student 17 9%
Other 37 19%
Unknown 12 6%
Readers by discipline Count As %
Agricultural and Biological Sciences 61 32%
Biochemistry, Genetics and Molecular Biology 43 23%
Medicine and Dentistry 34 18%
Chemistry 9 5%
Neuroscience 5 3%
Other 22 12%
Unknown 16 8%

Attention Score in Context

This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 May 2018.
All research outputs
#1,453,882
of 14,746,358 outputs
Outputs from Journal of Biological Chemistry
#1,530
of 56,348 outputs
Outputs of similar age
#30,545
of 281,276 outputs
Outputs of similar age from Journal of Biological Chemistry
#28
of 472 outputs
Altmetric has tracked 14,746,358 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 56,348 research outputs from this source. They receive a mean Attention Score of 4.4. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 281,276 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 472 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.