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The dimerization domain of HIV-1 viral infectivity factor Vif is required to block virion incorporation of APOBEC3G

Overview of attention for article published in Retrovirology: Research & Treatment, January 2007
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (68th percentile)
  • Good Attention Score compared to outputs of the same age and source (77th percentile)

Mentioned by

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2 Wikipedia pages

Citations

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42 Dimensions

Readers on

mendeley
58 Mendeley
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Title
The dimerization domain of HIV-1 viral infectivity factor Vif is required to block virion incorporation of APOBEC3G
Published in
Retrovirology: Research & Treatment, January 2007
DOI 10.1186/1742-4690-4-81
Pubmed ID
Authors

James H Miller, Vlad Presnyak, Harold C Smith

Abstract

The HIV-1 accessory protein known as viral infectivity factor or Vif binds to the host defence factor human APOBEC3G (hA3G) and prevents its assembly with viral particles and mediates its elimination through ubiquitination and degradation by the proteosomal pathway. In the absence of Vif, hA3G becomes incorporated within viral particles. During the post entry phase of infection, hA3G attenuates viral replication by binding to the viral RNA genome and deaminating deoxycytidines to form deoxyuridines within single stranded DNA regions of the replicated viral genome. Vif dimerization has been reported to be essential for viral infectivity but the mechanistic requirement for Vif multimerization is unknown.

Mendeley readers

The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 3 5%
United States 3 5%
France 1 2%
Spain 1 2%
Unknown 50 86%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 15 26%
Researcher 15 26%
Student > Master 8 14%
Student > Bachelor 6 10%
Student > Doctoral Student 3 5%
Other 9 16%
Unknown 2 3%
Readers by discipline Count As %
Agricultural and Biological Sciences 32 55%
Chemistry 7 12%
Biochemistry, Genetics and Molecular Biology 6 10%
Medicine and Dentistry 3 5%
Computer Science 1 2%
Other 4 7%
Unknown 5 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 June 2014.
All research outputs
#917,652
of 3,992,024 outputs
Outputs from Retrovirology: Research & Treatment
#146
of 652 outputs
Outputs of similar age
#37,423
of 124,125 outputs
Outputs of similar age from Retrovirology: Research & Treatment
#6
of 27 outputs
Altmetric has tracked 3,992,024 research outputs across all sources so far. This one has received more attention than most of these and is in the 63rd percentile.
So far Altmetric has tracked 652 research outputs from this source. They receive a mean Attention Score of 3.6. This one has gotten more attention than average, scoring higher than 71% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 124,125 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 27 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 77% of its contemporaries.