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Association between diabetes and causes of dementia: Evidence from a clinicopathological study

Overview of attention for article published in Dementia & Neuropsychologia, December 2017
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Mentioned by

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3 tweeters

Citations

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12 Dimensions

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23 Mendeley
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Title
Association between diabetes and causes of dementia: Evidence from a clinicopathological study
Published in
Dementia & Neuropsychologia, December 2017
DOI 10.1590/1980-57642016dn11-040010
Pubmed ID
Authors

Maria Niures Pimentel dos Santos Matioli, Claudia Kimie Suemoto, Roberta Diehl Rodriguez, Daniela Souza Farias, Magnólia Moreira da Silva, Renata Elaine Paraizo Leite, Renata Eloah Lucena Ferretti-Rebustini, Carlos Augusto Pasqualucci, Wilson Jacob Filho, Lea Tenenholz Grinberg, Ricardo Nitrini

Abstract

Diabetes mellitus is a risk factor for dementia, especially for vascular dementia (VaD), but there is no consensus on diabetes as a risk factor for Alzheimer's disease (AD) and other causes of dementia. To explore the association between diabetes and the neuropathological etiology of dementia in a large autopsy study. Data were collected from the participants of the Brain Bank of the Brazilian Aging Brain Study Group between 2004 and 2015. Diagnosis of diabetes was reported by the deceased's next-of-kin. Clinical dementia was established when CDR ≥ 1 and IQCODE > 3.41. Dementia etiology was determined by neuropathological examination using immunohistochemistry. The association of diabetes with odds of dementia was investigated using multivariate logistic regression. We included 1,037 subjects and diabetes was present in 279 participants (27%). The prevalence of dementia diagnosis was similar in diabetics (29%) and non-diabetics (27%). We found no association between diabetes and dementia (OR = 1.22; 95%CI = 0.81-1.82; p = 0.34) on the multivariate analysis. AD was the main cause of dementia in both groups, while VaD was the second-most-frequent cause in diabetics. Other mixed dementia was the second-most-common cause of dementia and more frequent among non-diabetics (p = 0.03). Diabetes was not associated with dementia in this large clinicopathological study.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 23 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 3 13%
Student > Ph. D. Student 1 4%
Student > Master 1 4%
Unknown 18 78%
Readers by discipline Count As %
Medicine and Dentistry 2 9%
Biochemistry, Genetics and Molecular Biology 1 4%
Pharmacology, Toxicology and Pharmaceutical Science 1 4%
Immunology and Microbiology 1 4%
Neuroscience 1 4%
Other 0 0%
Unknown 17 74%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 February 2018.
All research outputs
#8,308,523
of 13,786,654 outputs
Outputs from Dementia & Neuropsychologia
#63
of 104 outputs
Outputs of similar age
#150,965
of 271,143 outputs
Outputs of similar age from Dementia & Neuropsychologia
#1
of 1 outputs
Altmetric has tracked 13,786,654 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 104 research outputs from this source. They receive a mean Attention Score of 3.7. This one is in the 38th percentile – i.e., 38% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 271,143 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them