↓ Skip to main content

Genetics of the human Y chromosome and its association with male infertility

Overview of attention for article published in Reproductive Biology and Endocrinology, February 2018
Altmetric Badge

About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (89th percentile)

Mentioned by

twitter
22 tweeters
facebook
1 Facebook page
wikipedia
3 Wikipedia pages
googleplus
2 Google+ users

Citations

dimensions_citation
139 Dimensions

Readers on

mendeley
296 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Genetics of the human Y chromosome and its association with male infertility
Published in
Reproductive Biology and Endocrinology, February 2018
DOI 10.1186/s12958-018-0330-5
Pubmed ID
Authors

Stacy Colaco, Deepak Modi

Abstract

The human Y chromosome harbors genes that are responsible for testis development and also for initiation and maintenance of spermatogenesis in adulthood. The long arm of the Y chromosome (Yq) contains many ampliconic and palindromic sequences making it predisposed to self-recombination during spermatogenesis and hence susceptible to intra-chromosomal deletions. Such deletions lead to copy number variation in genes of the Y chromosome resulting in male infertility. Three common Yq deletions that recur in infertile males are termed as AZF (Azoospermia Factor) microdeletions viz. AZFa, AZFb and AZFc. As estimated from data of nearly 40,000 Y chromosomes, the global prevalence of Yq microdeletions is 7.5% in infertile males; however the European infertile men are less susceptible to Yq microdeletions, the highest prevalence is in Americans and East Asian infertile men. In addition, partial deletions of the AZFc locus have been associated with infertility but the effect seems to be ethnicity dependent. Analysis of > 17,000 Y chromosomes from fertile and infertile men has revealed an association of gr/gr deletion with male infertility in Caucasians and Mongolian men, while the b2/b3 deletion is associated with male infertility in African and Dravidian men. Clinically, the screening for Yq microdeletions would aid the clinician in determining the cause of male infertility and decide a rational management strategy for the patient. As these deletions are transmitted to 100% of male offspring born through assisted reproduction, testing of Yq deletions will allow the couples to make an informed choice regarding the perpetuation of male infertility in future generations. With the emerging data on association of Yq deletions with testicular cancers and neuropsychiatric conditions long term follow-up data is urgently needed for infertile men harboring Yq deletions. If found so, the information will change the current the perspective of androgenetics from infertility and might have broad implication in men health.

Twitter Demographics

The data shown below were collected from the profiles of 22 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 296 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 296 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 45 15%
Student > Bachelor 44 15%
Researcher 30 10%
Student > Ph. D. Student 24 8%
Student > Postgraduate 19 6%
Other 45 15%
Unknown 89 30%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 88 30%
Medicine and Dentistry 52 18%
Agricultural and Biological Sciences 24 8%
Neuroscience 6 2%
Immunology and Microbiology 5 2%
Other 22 7%
Unknown 99 33%

Attention Score in Context

This research output has an Altmetric Attention Score of 22. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 November 2022.
All research outputs
#1,457,862
of 22,562,129 outputs
Outputs from Reproductive Biology and Endocrinology
#59
of 962 outputs
Outputs of similar age
#32,046
of 295,566 outputs
Outputs of similar age from Reproductive Biology and Endocrinology
#1
of 1 outputs
Altmetric has tracked 22,562,129 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 962 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.9. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 295,566 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them