Title |
T cell-NF-κB activation is required for tumor control in vivo
|
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Published in |
Journal for Immunotherapy of Cancer, January 2015
|
DOI | 10.1186/s40425-014-0045-x |
Pubmed ID | |
Authors |
Sarah E Barnes, Ying Wang, Luqiu Chen, Luciana L Molinero, Thomas F Gajewski, Cesar Evaristo, Maria-Luisa Alegre |
Abstract |
T cells have the capacity to eliminate tumors but the signaling pathways by which they do so are incompletely understood. T cell priming requires activation of the transcription factors AP-1, NFAT and NF-κB downstream of the TCR, but whether activation of T cell-NF-κB in vivo is required for tumor control has not been addressed. In humans and mice with progressively growing tumors, the activity of T cell-intrinsic NF-κB is often reduced. However, it is not clear if this is causal for an inability to reject transformed cells, or if it is a consequence of tumor growth. T cell-NF-κB is important for T cell survival and effector differentiation and plays an important role in enabling T cells to reject cardiac and islet allografts, suggesting the possibility that it may also be required for tumor elimination. In this study, we tested whether normal T cell-NF-κB activation is necessary for the rejection of tumors whose growth is normally controlled by the immune system. |
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Geographical breakdown
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Unknown | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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United States | 1 | 2% |
Germany | 1 | 2% |
Unknown | 62 | 97% |
Demographic breakdown
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Student > Ph. D. Student | 22 | 34% |
Researcher | 11 | 17% |
Student > Doctoral Student | 5 | 8% |
Student > Master | 5 | 8% |
Student > Bachelor | 4 | 6% |
Other | 6 | 9% |
Unknown | 11 | 17% |
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Agricultural and Biological Sciences | 14 | 22% |
Biochemistry, Genetics and Molecular Biology | 10 | 16% |
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Psychology | 1 | 2% |
Other | 1 | 2% |
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