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Intrahepatic cholestasis of pregnancy

Overview of attention for article published in Orphanet Journal of Rare Diseases, May 2007
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (66th percentile)
  • Good Attention Score compared to outputs of the same age and source (65th percentile)

Mentioned by

wikipedia
3 Wikipedia pages

Citations

dimensions_citation
99 Dimensions

Readers on

mendeley
89 Mendeley
citeulike
2 CiteULike
connotea
1 Connotea
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Title
Intrahepatic cholestasis of pregnancy
Published in
Orphanet Journal of Rare Diseases, May 2007
DOI 10.1186/1750-1172-2-26
Pubmed ID
Authors

Thomas Pusl, Ulrich Beuers

Abstract

Intrahepatic cholestasis of pregnancy (ICP) is a cholestatic disorder characterized by (i) pruritus with onset in the second or third trimester of pregnancy, (ii) elevated serum aminotransferases and bile acid levels, and (iii) spontaneous relief of signs and symptoms within two to three weeks after delivery. ICP is observed in 0.4-1% of pregnancies in most areas of Central and Western Europe and North America, while in Chile and Bolivia as well as Scandinavia and the Baltic states roughly 5-15% and 1-2%, respectively, of pregnancies are associated with ICP. Genetic and hormonal factors, but also environmental factors may contribute to the pathogenesis of ICP. Intrahepatic cholestasis of pregnancy increases the risk of preterm delivery (19-60%), meconium staining of amniotic fluid (27%), fetal bradycardia (14%), fetal distress (22-41%), and fetal loss (0.4-4.1%), particularly when associated with fasting serum bile acid levels > 40 micromol/L. The hydrophilic bile acid ursodeoxycholic acid (10-20 mg/kg/d) is today regarded as the first line treatment for intrahepatic cholestasis of pregnancy. Delivery has been recommended in the 38th week when lung maturity has been established.

Mendeley readers

The data shown below were compiled from readership statistics for 89 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 1%
France 1 1%
India 1 1%
Mexico 1 1%
Spain 1 1%
Unknown 84 94%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 16 18%
Researcher 12 13%
Student > Postgraduate 11 12%
Student > Ph. D. Student 9 10%
Other 8 9%
Other 23 26%
Unknown 10 11%
Readers by discipline Count As %
Medicine and Dentistry 60 67%
Agricultural and Biological Sciences 10 11%
Biochemistry, Genetics and Molecular Biology 3 3%
Computer Science 1 1%
Pharmacology, Toxicology and Pharmaceutical Science 1 1%
Other 4 4%
Unknown 10 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 December 2017.
All research outputs
#3,603,585
of 12,439,665 outputs
Outputs from Orphanet Journal of Rare Diseases
#525
of 1,352 outputs
Outputs of similar age
#78,039
of 266,499 outputs
Outputs of similar age from Orphanet Journal of Rare Diseases
#11
of 35 outputs
Altmetric has tracked 12,439,665 research outputs across all sources so far. This one is in the 49th percentile – i.e., 49% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,352 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one has gotten more attention than average, scoring higher than 56% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,499 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 35 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.