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Allopurinol partially prevents disuse muscle atrophy in mice and humans

Overview of attention for article published in Scientific Reports, February 2018
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (73rd percentile)
  • High Attention Score compared to outputs of the same age and source (87th percentile)

Mentioned by

twitter
9 tweeters

Citations

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4 Dimensions

Readers on

mendeley
34 Mendeley
Title
Allopurinol partially prevents disuse muscle atrophy in mice and humans
Published in
Scientific Reports, February 2018
DOI 10.1038/s41598-018-21552-1
Pubmed ID
Authors

Beatriz Ferrando, Mari Carmen Gomez-Cabrera, Andrea Salvador-Pascual, Carlos Puchades, Frederic Derbré, Arlette Gratas-Delamarche, Ludovic Laparre, Gloria Olaso-Gonzalez, Miguel Cerda, Enrique Viosca, Ana Alabajos, Vicente Sebastiá, Angel Alberich-Bayarri, Fabio García-Castro, Jose Viña

Abstract

Disuse muscle wasting will likely affect everyone in his or her lifetime in response to pathologies such as joint immobilization, inactivity or bed rest. There are no good therapies to treat it. We previously found that allopurinol, a drug widely used to treat gout, protects muscle damage after exhaustive exercise and results in functional gains in old individuals. Thus, we decided to test its effect in the prevention of soleus muscle atrophy after two weeks of hindlimb unloading in mice, and lower leg immobilization following ankle sprain in humans (EudraCT: 2011-003541-17). Our results show that allopurinol partially protects against muscle atrophy in both mice and humans. The protective effect of allopurinol is similar to that of resistance exercise which is the best-known way to prevent muscle mass loss in disuse human models. We report that allopurinol protects against the loss of muscle mass by inhibiting the expression of ubiquitin ligases. Our results suggest that the ubiquitin-proteasome pathway is an appropriate therapeutic target to inhibit muscle wasting and emphasizes the role of allopurinol as a non-hormonal intervention to treat disuse muscle atrophy.

Twitter Demographics

The data shown below were collected from the profiles of 9 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 34 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 6 18%
Student > Master 5 15%
Researcher 5 15%
Student > Doctoral Student 3 9%
Student > Ph. D. Student 3 9%
Other 3 9%
Unknown 9 26%
Readers by discipline Count As %
Medicine and Dentistry 6 18%
Nursing and Health Professions 5 15%
Biochemistry, Genetics and Molecular Biology 5 15%
Agricultural and Biological Sciences 4 12%
Immunology and Microbiology 1 3%
Other 2 6%
Unknown 11 32%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 April 2019.
All research outputs
#2,418,690
of 13,606,339 outputs
Outputs from Scientific Reports
#17,923
of 67,005 outputs
Outputs of similar age
#71,311
of 271,020 outputs
Outputs of similar age from Scientific Reports
#1
of 8 outputs
Altmetric has tracked 13,606,339 research outputs across all sources so far. Compared to these this one has done well and is in the 82nd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 67,005 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.7. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 271,020 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them