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Toxoplasma gondii alters NMDAR signaling and induces signs of Alzheimer’s disease in wild-type, C57BL/6 mice

Overview of attention for article published in Journal of Neuroinflammation, February 2018
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  • Above-average Attention Score compared to outputs of the same age and source (64th percentile)

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Title
Toxoplasma gondii alters NMDAR signaling and induces signs of Alzheimer’s disease in wild-type, C57BL/6 mice
Published in
Journal of Neuroinflammation, February 2018
DOI 10.1186/s12974-018-1086-8
Pubmed ID
Authors

Luisa Torres, Sudie-Ann Robinson, Do-Geun Kim, Angela Yan, Thomas A. Cleland, Margaret S. Bynoe

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disease associated with cognitive decline and complete loss of basic functions. The ubiquitous apicomplexan parasite Toxoplasma gondii (T. gondii) infects up to one third of the world's population and is implicated in AD. We infected C57BL/6 wild-type male and female mice with 10 T. gondii ME49 cysts and assessed whether infection led to behavioral and anatomical effects using immunohistochemistry, immunofluorescence, Western blotting, cell culture assays, as well as an array of mouse behavior tests. We show that T. gondii infection induced two major hallmarks of AD in the brains of C57BL/6 male and female mice: beta-amyloid (Aβ) immunoreactivity and hyperphosphorylated Tau. Infected mice showed significant neuronal death, loss of N-methyl-D-aspartate receptor (NMDAR) expression, and loss of olfactory sensory neurons. T. gondii infection also caused anxiety-like behavior, altered recognition of social novelty, altered spatial memory, and reduced olfactory sensitivity. This last finding was exclusive to male mice, as infected females showed intact olfactory sensitivity. These results demonstrate that T. gondii can induce advanced signs of AD in wild-type mice and that it may induce AD in some individuals with underlying health problems.

X Demographics

X Demographics

The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 85 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 85 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 17 20%
Student > Ph. D. Student 13 15%
Student > Master 10 12%
Student > Doctoral Student 5 6%
Researcher 5 6%
Other 10 12%
Unknown 25 29%
Readers by discipline Count As %
Agricultural and Biological Sciences 13 15%
Neuroscience 11 13%
Biochemistry, Genetics and Molecular Biology 10 12%
Immunology and Microbiology 7 8%
Medicine and Dentistry 4 5%
Other 8 9%
Unknown 32 38%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 October 2023.
All research outputs
#6,946,184
of 25,282,542 outputs
Outputs from Journal of Neuroinflammation
#1,212
of 2,926 outputs
Outputs of similar age
#111,771
of 336,719 outputs
Outputs of similar age from Journal of Neuroinflammation
#25
of 68 outputs
Altmetric has tracked 25,282,542 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 2,926 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.7. This one has gotten more attention than average, scoring higher than 58% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 336,719 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 68 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.