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The Retinoblastoma Protein

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Cover of 'The Retinoblastoma Protein'

Table of Contents

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    Book Overview
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    Chapter 1 Characterization of RB1 Deletions in Interphase and Metaphase by Molecular Cytogenetics Exemplified in Chronic Lymphatic Leukemia
  3. Altmetric Badge
    Chapter 2 Detection of RB1 Gene Copy Number Variations Using a Multiplex Ligation-Dependent Probe Amplification Method
  4. Altmetric Badge
    Chapter 3 A Fluorescent Quantitative Multiplex PCR Method to Detect Copy Number Changes in the RB1 Gene
  5. Altmetric Badge
    Chapter 4 Using Methylation-Specific PCR to Study RB1 Promoter Hypermethylation
  6. Altmetric Badge
    Chapter 5 Detection of Aberrant DNA Methylation Patterns in the RB1 Gene
  7. Altmetric Badge
    Chapter 6 Detection of Retinoblastoma Protein Phosphorylation by Immunoblot Analysis
  8. Altmetric Badge
    Chapter 7 Immunohistochemical Detection of the Retinoblastoma Protein
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    Chapter 8 Immunohistochemical Detection of Retinoblastoma Protein Phosphorylation in Human Tumor Samples
  10. Altmetric Badge
    Chapter 9 Detection of CCND1 Locus Amplification by Fluorescence In Situ Hybridization
  11. Altmetric Badge
    Chapter 10 Detection of CCND1 Gene Copy Number Variations Using Multiplex Ligation-Dependent Probe Amplification and Fluorescence In Situ Hybridization Methods
  12. Altmetric Badge
    Chapter 11 Detection of p16 Promoter Hypermethylation by Methylation-Specific PCR
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    Chapter 12 Immunohistochemical Detection of p16 in Clinical Samples
  14. Altmetric Badge
    Chapter 13 Detection of E2F-DNA Complexes Using Chromatin Immunoprecipitation Assays
  15. Altmetric Badge
    Chapter 14 Detection of E2F-Induced Transcriptional Activity Using a Dual Luciferase Reporter Assay
  16. Altmetric Badge
    Chapter 15 Detection of HPV E6/E7 mRNA in Clinical Samples Using RNA In Situ Hybridization
  17. Altmetric Badge
    Chapter 16 CRISPR/Cas9-Mediated Knockout of Rb1 in Xenopus tropicalis
Attention for Chapter 1: Characterization of RB1 Deletions in Interphase and Metaphase by Molecular Cytogenetics Exemplified in Chronic Lymphatic Leukemia
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Chapter title
Characterization of RB1 Deletions in Interphase and Metaphase by Molecular Cytogenetics Exemplified in Chronic Lymphatic Leukemia
Chapter number 1
Book title
The Retinoblastoma Protein
Published in
Methods in molecular biology, January 2018
DOI 10.1007/978-1-4939-7565-5_1
Pubmed ID
Book ISBNs
978-1-4939-7564-8, 978-1-4939-7565-5
Authors

Thomas Liehr, Liehr, Thomas

Abstract

In chronic lymphatic leukemia (CLL), detection and characterization of prognostic relevant chromosomal alterations is optimally done by interphase-fluorescence in situ hybridization (iFISH). Interphase nuclei derived from blood smears, bone marrow smears or from cultivated and conventionally prepared blood or bone marrow cells can be used. In CLL heterozygous or even homozygous deletion of RB1 can be found. Interestingly an iFISH diagnostic result with RB1 deletion as sole aberration is indicative for a favorable course of the disease. Here we describe the best way how to detect RB1 deletion in CLL.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 1 Mendeley reader of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 1 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 1 100%
Readers by discipline Count As %
Immunology and Microbiology 1 100%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 January 2019.
All research outputs
#18,589,103
of 23,025,074 outputs
Outputs from Methods in molecular biology
#7,969
of 13,170 outputs
Outputs of similar age
#330,567
of 442,364 outputs
Outputs of similar age from Methods in molecular biology
#950
of 1,499 outputs
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