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The Retinoblastoma Protein

Overview of attention for book
Cover of 'The Retinoblastoma Protein'

Table of Contents

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    Book Overview
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    Chapter 1 Characterization of RB1 Deletions in Interphase and Metaphase by Molecular Cytogenetics Exemplified in Chronic Lymphatic Leukemia
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    Chapter 2 Detection of RB1 Gene Copy Number Variations Using a Multiplex Ligation-Dependent Probe Amplification Method
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    Chapter 3 A Fluorescent Quantitative Multiplex PCR Method to Detect Copy Number Changes in the RB1 Gene
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    Chapter 4 Using Methylation-Specific PCR to Study RB1 Promoter Hypermethylation
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    Chapter 5 Detection of Aberrant DNA Methylation Patterns in the RB1 Gene
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    Chapter 6 Detection of Retinoblastoma Protein Phosphorylation by Immunoblot Analysis
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    Chapter 7 Immunohistochemical Detection of the Retinoblastoma Protein
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    Chapter 8 Immunohistochemical Detection of Retinoblastoma Protein Phosphorylation in Human Tumor Samples
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    Chapter 9 Detection of CCND1 Locus Amplification by Fluorescence In Situ Hybridization
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    Chapter 10 Detection of CCND1 Gene Copy Number Variations Using Multiplex Ligation-Dependent Probe Amplification and Fluorescence In Situ Hybridization Methods
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    Chapter 11 Detection of p16 Promoter Hypermethylation by Methylation-Specific PCR
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    Chapter 12 Immunohistochemical Detection of p16 in Clinical Samples
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    Chapter 13 Detection of E2F-DNA Complexes Using Chromatin Immunoprecipitation Assays
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    Chapter 14 Detection of E2F-Induced Transcriptional Activity Using a Dual Luciferase Reporter Assay
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    Chapter 15 Detection of HPV E6/E7 mRNA in Clinical Samples Using RNA In Situ Hybridization
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    Chapter 16 CRISPR/Cas9-Mediated Knockout of Rb1 in Xenopus tropicalis
Attention for Chapter 2: Detection of RB1 Gene Copy Number Variations Using a Multiplex Ligation-Dependent Probe Amplification Method
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Chapter title
Detection of RB1 Gene Copy Number Variations Using a Multiplex Ligation-Dependent Probe Amplification Method
Chapter number 2
Book title
The Retinoblastoma Protein
Published in
Methods in molecular biology, January 2018
DOI 10.1007/978-1-4939-7565-5_2
Pubmed ID
29468539
Book ISBNs
978-1-4939-7564-8, 978-1-4939-7565-5
Authors

Nejat Dalay

Abstract

Multiplex ligation-dependent probe amplification (MLPA) is based on simultaneous multiplex PCR of specific probes that hybridize to multiple different target DNA regions. The method can identify copy number changes, gross gene rearrangements, methylation patterns or even point mutations. MLPA has been a reliable approach to identify copy number changes in the clinical and research settings and is widely used for the screening and investigation of copy number variations and genomic aberrations of interest in various diseases. In this chapter the analysis of the copy number changes in the RB1 gene locus by MLPA is described.

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Mendeley readers

The data shown below were compiled from readership statistics for 3 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 3 100%

Demographic breakdown

Readers by professional status Count As %
Lecturer 1 33%
Unknown 2 67%
Readers by discipline Count As %
Neuroscience 1 33%
Unknown 2 67%

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