Title |
Emerging Coxsackievirus A6 Causing Hand, Foot and Mouth Disease, Vietnam - Volume 24, Number 4—April 2018 - Emerging Infectious Diseases journal - CDC
|
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Published in |
Emerging Infectious Diseases, April 2018
|
DOI | 10.3201/eid2404.171298 |
Pubmed ID | |
Authors |
Nguyen To Anh, Le Nguyen Truc Nhu, Hoang Minh Tu Van, Nguyen Thi Thu Hong, Tran Tan Thanh, Vu Thi Ty Hang, Nguyen Thi Han Ny, Lam Anh Nguyet, Tran Thi Lan Phuong, Le Nguyen Thanh Nhan, Nguyen Thanh Hung, Truong Huu Khanh, Ha Manh Tuan, Ho Lu Viet, Nguyen Tran Nam, Do Chau Viet, Phan Tu Qui, Bridget Wills, Sarawathy Sabanathan, Nguyen Van Vinh Chau, Louise Thwaites, H Rogier van Doorn, Guy Thwaites, Maia A Rabaa, Le Van Tan |
Abstract |
Hand, foot and mouth disease (HFMD) is a major public health issue in Asia and has global pandemic potential. Coxsackievirus A6 (CV-A6) was detected in 514/2,230 (23%) of HFMD patients admitted to 3 major hospitals in southern Vietnam during 2011-2015. Of these patients, 93 (18%) had severe HFMD. Phylogenetic analysis of 98 genome sequences revealed they belonged to cluster A and had been circulating in Vietnam for 2 years before emergence. CV-A6 movement among localities within Vietnam occurred frequently, whereas viral movement across international borders appeared rare. Skyline plots identified fluctuations in the relative genetic diversity of CV-A6 corresponding to large CV-A6-associated HFMD outbreaks worldwide. These data show that CV-A6 is an emerging pathogen and emphasize the necessity of active surveillance and understanding the mechanisms that shape the pathogen evolution and emergence, which is essential for development and implementation of intervention strategies. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Vietnam | 2 | 11% |
United States | 2 | 11% |
United Kingdom | 2 | 11% |
South Africa | 1 | 5% |
Singapore | 1 | 5% |
Unknown | 11 | 58% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 11 | 58% |
Practitioners (doctors, other healthcare professionals) | 4 | 21% |
Scientists | 3 | 16% |
Science communicators (journalists, bloggers, editors) | 1 | 5% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 65 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 12 | 18% |
Researcher | 10 | 15% |
Student > Bachelor | 9 | 14% |
Student > Ph. D. Student | 6 | 9% |
Other | 3 | 5% |
Other | 8 | 12% |
Unknown | 17 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 14 | 22% |
Biochemistry, Genetics and Molecular Biology | 10 | 15% |
Immunology and Microbiology | 6 | 9% |
Agricultural and Biological Sciences | 3 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 5% |
Other | 11 | 17% |
Unknown | 18 | 28% |