Title |
Factors that influence adult neurogenesis as potential therapy
|
---|---|
Published in |
Translational Neurodegeneration, February 2018
|
DOI | 10.1186/s40035-018-0109-9 |
Pubmed ID | |
Authors |
Belal Shohayeb, Mohamed Diab, Mazen Ahmed, Dominic Chi Hiung Ng |
Abstract |
Adult neurogenesis involves persistent proliferative neuroprogenitor populations that reside within distinct regions of the brain. This phenomenon was first described over 50 years ago and it is now firmly established that new neurons are continually generated in distinct regions of the adult brain. The potential of enhancing the neurogenic process lies in improved brain cognition and neuronal plasticity particularly in the context of neuronal injury and neurodegenerative disorders. In addition, adult neurogenesis might also play a role in mood and affective disorders. The factors that regulate adult neurogenesis have been broadly studied. However, the underlying molecular mechanisms of regulating neurogenesis are still not fully defined. In this review, we will provide critical analysis of our current understanding of the factors and molecular mechanisms that determine neurogenesis. We will further discuss pre-clinical and clinical studies that have investigated the potential of modulating neurogenesis as therapeutic intervention in neurodegeneration. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Australia | 2 | 50% |
Germany | 1 | 25% |
Unknown | 1 | 25% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 75% |
Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 270 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 42 | 16% |
Student > Bachelor | 41 | 15% |
Student > Ph. D. Student | 27 | 10% |
Researcher | 22 | 8% |
Student > Doctoral Student | 10 | 4% |
Other | 34 | 13% |
Unknown | 94 | 35% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 65 | 24% |
Biochemistry, Genetics and Molecular Biology | 33 | 12% |
Agricultural and Biological Sciences | 21 | 8% |
Medicine and Dentistry | 11 | 4% |
Pharmacology, Toxicology and Pharmaceutical Science | 11 | 4% |
Other | 29 | 11% |
Unknown | 100 | 37% |