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Comparative Genomic Analysis of 60 Mycobacteriophage Genomes: Genome Clustering, Gene Acquisition, and Gene Size

Overview of attention for article published in Journal of Molecular Biology, March 2010
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (79th percentile)
  • High Attention Score compared to outputs of the same age and source (92nd percentile)

Mentioned by

policy
1 policy source
wikipedia
1 Wikipedia page

Citations

dimensions_citation
181 Dimensions

Readers on

mendeley
162 Mendeley
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4 CiteULike
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Title
Comparative Genomic Analysis of 60 Mycobacteriophage Genomes: Genome Clustering, Gene Acquisition, and Gene Size
Published in
Journal of Molecular Biology, March 2010
DOI 10.1016/j.jmb.2010.01.011
Pubmed ID
Authors

Graham F. Hatfull, Deborah Jacobs-Sera, Jeffrey G. Lawrence, Welkin H. Pope, Daniel A. Russell, Ching-Chung Ko, Rebecca J. Weber, Manisha C. Patel, Katherine L. Germane, Robert H. Edgar, Natasha N. Hoyte, Charles A. Bowman, Anthony T. Tantoco, Elizabeth C. Paladin, Marlana S. Myers, Alexis L. Smith, Molly S. Grace, Thuy T. Pham, Matthew B. O'Brien, Amy M. Vogelsberger, Andrew J. Hryckowian, Jessica L. Wynalek, Helen Donis-Keller, Matt W. Bogel, Craig L. Peebles, Steven G. Cresawn, Roger W. Hendrix

Abstract

Mycobacteriophages are viruses that infect mycobacterial hosts. Expansion of a collection of sequenced phage genomes to a total of 60-all infecting a common bacterial host-provides further insight into their diversity and evolution. Of the 60 phage genomes, 55 can be grouped into nine clusters according to their nucleotide sequence similarities, 5 of which can be further divided into subclusters; 5 genomes do not cluster with other phages. The sequence diversity between genomes within a cluster varies greatly; for example, the 6 genomes in Cluster D share more than 97.5% average nucleotide similarity with one another. In contrast, similarity between the 2 genomes in Cluster I is barely detectable by diagonal plot analysis. In total, 6858 predicted open-reading frames have been grouped into 1523 phamilies (phams) of related sequences, 46% of which possess only a single member. Only 18.8% of the phams have sequence similarity to non-mycobacteriophage database entries, and fewer than 10% of all phams can be assigned functions based on database searching or synteny. Genome clustering facilitates the identification of genes that are in greatest genetic flux and are more likely to have been exchanged horizontally in relatively recent evolutionary time. Although mycobacteriophage genes exhibit a smaller average size than genes of their host (205 residues compared with 315), phage genes in higher flux average only 100 amino acids, suggesting that the primary units of genetic exchange correspond to single protein domains.

Mendeley readers

The data shown below were compiled from readership statistics for 162 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 2%
Brazil 2 1%
Canada 2 1%
South Africa 1 <1%
India 1 <1%
Turkey 1 <1%
Unknown 152 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 45 28%
Student > Bachelor 40 25%
Researcher 25 15%
Student > Doctoral Student 9 6%
Professor 8 5%
Other 25 15%
Unknown 10 6%
Readers by discipline Count As %
Agricultural and Biological Sciences 92 57%
Biochemistry, Genetics and Molecular Biology 32 20%
Immunology and Microbiology 7 4%
Environmental Science 5 3%
Computer Science 3 2%
Other 11 7%
Unknown 12 7%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 February 2012.
All research outputs
#2,089,189
of 12,196,798 outputs
Outputs from Journal of Molecular Biology
#1,149
of 9,325 outputs
Outputs of similar age
#53,857
of 271,172 outputs
Outputs of similar age from Journal of Molecular Biology
#6
of 77 outputs
Altmetric has tracked 12,196,798 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 9,325 research outputs from this source. They receive a mean Attention Score of 4.3. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 271,172 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 77 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.