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FoxP3 isoforms and PD-1 expression by T regulatory cells in multiple sclerosis

Overview of attention for article published in Scientific Reports, February 2018
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (86th percentile)
  • High Attention Score compared to outputs of the same age and source (83rd percentile)

Mentioned by

news
1 news outlet
twitter
8 tweeters

Citations

dimensions_citation
19 Dimensions

Readers on

mendeley
67 Mendeley
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Title
FoxP3 isoforms and PD-1 expression by T regulatory cells in multiple sclerosis
Published in
Scientific Reports, February 2018
DOI 10.1038/s41598-018-21861-5
Pubmed ID
Authors

Manolo Sambucci, Francesca Gargano, Veronica De Rosa, Marco De Bardi, Mario Picozza, Roberta Placido, Serena Ruggieri, Alessia Capone, Claudio Gasperini, Giuseppe Matarese, Luca Battistini, Giovanna Borsellino

Abstract

Forkhead box P3 (FoxP3)+ regulatory T cells (Treg) are powerful mediators of immune regulation and immune homeostasis. In humans, Tregs are a heterogeneous population expressing surface markers which define phenotypically and functionally distinct subsets. Moreover, it is now clear that intracellular staining for FoxP3 does not unequivocally identify "true" suppressor cells, since several FoxP3 isoforms exist, and different reagents for FoxP3 detection are available. Here, we propose a strategy to identify potentially functional and suppressive Treg cells in an autoimmune disease like multiple sclerosis, and we suggest that in patients affected by this disease these cells are both reduced in number and functionally exhausted.

Twitter Demographics

The data shown below were collected from the profiles of 8 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 67 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 67 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 15%
Researcher 8 12%
Student > Master 8 12%
Other 7 10%
Student > Bachelor 7 10%
Other 11 16%
Unknown 16 24%
Readers by discipline Count As %
Immunology and Microbiology 16 24%
Biochemistry, Genetics and Molecular Biology 11 16%
Medicine and Dentistry 8 12%
Neuroscience 6 9%
Agricultural and Biological Sciences 5 7%
Other 2 3%
Unknown 19 28%

Attention Score in Context

This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 April 2018.
All research outputs
#1,063,750
of 14,036,037 outputs
Outputs from Scientific Reports
#9,772
of 71,159 outputs
Outputs of similar age
#36,653
of 274,562 outputs
Outputs of similar age from Scientific Reports
#1
of 6 outputs
Altmetric has tracked 14,036,037 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 71,159 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.5. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 274,562 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them