Title |
In vitro basal T-cell proliferation among asymptomatic Human T cell Leukemia Virus type 1 patients co-infected with hepatitis C and/or Human Immunodeficiency Virus type 1
|
---|---|
Published in |
Brazilian Journal of Infectious Diseases, February 2018
|
DOI | 10.1016/j.bjid.2018.02.002 |
Pubmed ID | |
Authors |
Tatiane Assone, Tatiana M. Kanashiro, Maira P.M. Baldassin, Arthur Paiva, Michel E. Haziot, Jerusa Smid, Augusto Penalva de Oliveira, Luiz Augusto M. Fonseca, Philip J. Norris, Jorge Casseb |
Abstract |
Infection with HTLV-1 can be associated with myelopathy/tropical spastic paraparesis (HAM/TSP) and other inflammatory diseases. Lymphocytes from about half of HTLV-1-infected subjects spontaneously proliferate in vitro, and how this phenomenon relates to symptomatic disease and viral burden is poorly understood. To evaluate T-cell proliferation in vitro among patients co-infected with HTLV-1/HCV/HIV-1. From 610 HTLV-infected patients of the HTLV outpatient clinic from Institute of Infectious Diseases "Emilio Ribas" in São Paulo, 273 agreed to participate: 72 had HAM/TSP (excluded from this analysis) and 201 were asymptomatic, a classification performed during a regular neurological appointment. We selected the subgroup made up only by the 201 asymptomatic subjects to avoid bias by the clinical status as a confounder effect, who had laboratory results of HTLV-1 proviral load and T-cell proliferation assay in our database. They were further grouped according to their serological status in four categories: 121 HTLV-1 asymptomatic mono-infected carriers; 32 HTLV-1/HCV, 29 HTLV-1/HIV-1, and 19 HTLV-1/HIV-1/HCV co-infected patients. Clinical data were obtained from medical records and interviews. DNA HTLV-1 proviral load (PVL) and T-cell proliferation (LPA) assay were performed for all samples. From a total of 273 subjects with HTLV-1, 80 presented co-infections: 29 had HIV-1, 32 had HCV, and 19 had HIV-1 and HCV. Comparing the groups based on their serological status, independently of being asymptomatic carriers, we observed a significant increase of PVL (p<0.001) and LPA (p=0.001). However, when groups were stratified according to their clinical and serological status, there was no significant increase in HTLV-1 PVL and LPA. No significant increase of basal T-cell proliferation among HTLV-1 co-infected was observed. This interaction may be implicated in liver damage, worsening the prognosis of co-infected patients or, on the contrary, inducing a higher spontaneous clearance of HCV infection in HTLV-1 co-infected patients. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 35 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Doctoral Student | 7 | 20% |
Student > Master | 5 | 14% |
Student > Bachelor | 4 | 11% |
Researcher | 3 | 9% |
Other | 2 | 6% |
Other | 3 | 9% |
Unknown | 11 | 31% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 11 | 31% |
Immunology and Microbiology | 2 | 6% |
Biochemistry, Genetics and Molecular Biology | 2 | 6% |
Agricultural and Biological Sciences | 1 | 3% |
Nursing and Health Professions | 1 | 3% |
Other | 4 | 11% |
Unknown | 14 | 40% |