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Natural Schistosoma mansoni infection in Nectomys squamipes: histopathological and morphometric analysis in comparison to experimentally infected N. squamipes and C3H/He mice

Overview of attention for article published in Memórias do Instituto Oswaldo Cruz, February 2003
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Title
Natural Schistosoma mansoni infection in Nectomys squamipes: histopathological and morphometric analysis in comparison to experimentally infected N. squamipes and C3H/He mice
Published in
Memórias do Instituto Oswaldo Cruz, February 2003
DOI 10.1590/s0074-02762002000900026
Pubmed ID
Authors

Michele Costa-Silva, Rosângela Rodrigues-Silva, Maarten Hulstijn, Renata Heisler Neves, Mônica de Souza Panasco, Henrique Leonel Lenzi, José Roberto Machado-Silva

Abstract

Histopathologic and morphometric (area, perimeter, major and minor diameters) analysis of hepatic granulomas isolated from twelve naturally infected Nectomys squamipes were compared to four experimentally infected ones and six C3H/He mice. Liver paraffin sections were stained for cells and extracellular matrix. Both groups of N. squamipes presented peculiar granulomas consisting predominantly of large macrophages, full of schistosome pigment, characterizing an exudative-macrophage granuloma type, smaller than the equivalent granuloma type in mouse. Naturally infected animals exhibited granulomas in different stages of development, including large number of involutional types. Morphometric analysis showed that all measurements were smaller in naturally infected animals than in other groups. The results demonstrated that both N. squamipes groups reproduced, with small variations, the hepatic granuloma aspects already described in cricetidium (Calomys callosus), showing a genetic tendency to set up strong macrophage responses and small granulomas. Unexpectedly, natural infection did not engender distinguished histopathological characteristics distinct from those derived from experimental single infection, showing changes predominantly secondary to the duration of infection. It appears that the variability of the inocula (and the number of infections?) interfere more with the quantity than with the quality of the pathological changes, denoting some morpho-functional determinism in the response to schistosomal infection dependent on the animal species.

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The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 5%
Unknown 20 95%

Demographic breakdown

Readers by professional status Count As %
Professor > Associate Professor 4 19%
Student > Ph. D. Student 3 14%
Student > Postgraduate 3 14%
Student > Bachelor 2 10%
Student > Master 2 10%
Other 4 19%
Unknown 3 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 7 33%
Environmental Science 2 10%
Biochemistry, Genetics and Molecular Biology 2 10%
Immunology and Microbiology 2 10%
Medicine and Dentistry 2 10%
Other 1 5%
Unknown 5 24%