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HIV-1 Vif, APOBEC, and Intrinsic Immunity

Overview of attention for article published in Retrovirology: Research & Treatment, January 2008
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (73rd percentile)
  • High Attention Score compared to outputs of the same age and source (81st percentile)

Mentioned by

wikipedia
1 Wikipedia page

Citations

dimensions_citation
248 Dimensions

Readers on

mendeley
250 Mendeley
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Title
HIV-1 Vif, APOBEC, and Intrinsic Immunity
Published in
Retrovirology: Research & Treatment, January 2008
DOI 10.1186/1742-4690-5-51
Pubmed ID
Authors

Ritu Goila-Gaur, Klaus Strebel

Abstract

Members of the APOBEC family of cellular cytidine deaminases represent a recently identified group of proteins that provide immunity to infection by retroviruses and protect the cell from endogenous mobile retroelements. Yet, HIV-1 is largely immune to the intrinsic antiviral effects of APOBEC proteins because it encodes Vif (viral infectivity factor), an accessory protein that is critical for in vivo replication of HIV-1. In the absence of Vif, APOBEC proteins are encapsidated by budding virus particles and either cause extensive cytidine to uridine editing of negative sense single-stranded DNA during reverse transcription or restrict virus replication through deaminase-independent mechanisms. Thus, the primary function of Vif is to prevent encapsidation of APOBEC proteins into viral particles. This is in part accomplished by the ability of Vif to induce the ubiquitin-dependent degradation of some of the APOBEC proteins. However, Vif is also able to prevent encapsidation of APOBEC3G and APOBEC3F through degradation-independent mechanism(s). The goal of this review is to recapitulate current knowledge of the functional interaction of HIV-1 and its Vif protein with the APOBEC3 subfamily of proteins and to summarize our present understanding of the mechanism of APOBEC3-dependent retrovirus restriction.

Mendeley readers

The data shown below were compiled from readership statistics for 250 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 7 3%
Brazil 5 2%
Portugal 3 1%
United Kingdom 2 <1%
South Africa 1 <1%
Netherlands 1 <1%
Hong Kong 1 <1%
Italy 1 <1%
Canada 1 <1%
Other 3 1%
Unknown 225 90%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 64 26%
Researcher 48 19%
Student > Bachelor 36 14%
Student > Master 30 12%
Professor > Associate Professor 15 6%
Other 38 15%
Unknown 19 8%
Readers by discipline Count As %
Agricultural and Biological Sciences 114 46%
Biochemistry, Genetics and Molecular Biology 37 15%
Medicine and Dentistry 28 11%
Immunology and Microbiology 19 8%
Chemistry 8 3%
Other 19 8%
Unknown 25 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 December 2008.
All research outputs
#817,791
of 3,627,074 outputs
Outputs from Retrovirology: Research & Treatment
#131
of 621 outputs
Outputs of similar age
#24,154
of 93,506 outputs
Outputs of similar age from Retrovirology: Research & Treatment
#5
of 27 outputs
Altmetric has tracked 3,627,074 research outputs across all sources so far. This one has received more attention than most of these and is in the 63rd percentile.
So far Altmetric has tracked 621 research outputs from this source. They receive a mean Attention Score of 3.3. This one has gotten more attention than average, scoring higher than 71% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 93,506 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 27 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.