Title |
Oncoproteomic profiling with antibody microarrays
|
---|---|
Published in |
Genome Medicine, July 2009
|
DOI | 10.1186/gm68 |
Pubmed ID | |
Authors |
Mohamed SS Alhamdani, Christoph Schröder, Jörg D Hoheisel |
Abstract |
The incidence of cancer and its associated mortality are increasing globally, indicating an urgent need to develop even more effective and sensitive sets of biomarkers that could help in early diagnosis and consequent intervention. Given that many cellular processes are carried out by proteins, cancer research has recently shifted toward an exploration of the full proteome for such discovery. Among the advanced methodologies that are being developed for analyzing the proteome, antibody microarrays have become a prominent tool for gathering the information required for a better understanding of disease biology, early detection, discrimination of tumors and monitoring of disease progression. Here, we review the technical aspects and challenges in the development and use of antibody microarray assays and examine recently reported applications in oncoproteomics. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 2% |
India | 1 | 2% |
Germany | 1 | 2% |
Unknown | 49 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 12 | 23% |
Student > Master | 11 | 21% |
Researcher | 10 | 19% |
Student > Bachelor | 7 | 13% |
Student > Doctoral Student | 2 | 4% |
Other | 7 | 13% |
Unknown | 3 | 6% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 23 | 44% |
Medicine and Dentistry | 11 | 21% |
Biochemistry, Genetics and Molecular Biology | 8 | 15% |
Chemistry | 3 | 6% |
Mathematics | 1 | 2% |
Other | 2 | 4% |
Unknown | 4 | 8% |