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Regulation of female reproduction by p53 and its family members

Overview of attention for article published in FASEB Journal, March 2011
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Mentioned by

peer_reviews
1 peer review site

Citations

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56 Dimensions

Readers on

mendeley
44 Mendeley
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Title
Regulation of female reproduction by p53 and its family members
Published in
FASEB Journal, March 2011
DOI 10.1096/fj.10-180166
Pubmed ID
Authors

Zhaohui Feng, Cen Zhang, Hey‐Joo Kang, Yvonne Sun, Haijian Wang, Asad Naqvi, Amanda K. Frank, Zev Rosenwaks, Maureen E. Murphy, Arnold J. Levine, Wenwei Hu

Abstract

Tumor suppressor p53 is crucial for embryonic implantation through transcriptional up-regulation of uterine leukemia inhibitory factor (LIF). This article reports that p53 and estrogen receptor α were activated in endometrial tissues during implantation to coordinately regulate LIF production. By using human p53 knockin (Hupki) mice carrying a single nucleotide polymorphism (SNP) at codon 72 (arginine/proline), the arginine allele was demonstrated to produce higher uterine LIF levels during implantation than the proline allele. In humans, the diversity of haplotypes of the p53 gene has decreased during evolution, because the arginine allele, existing in only a subset of haplotypes, is under positive selection. This observation is consistent with previous results showing that the proline allele is enriched in patients undergoing in vitro fertilization (IVF). Studies with p63- and p73-knockout mice have demonstrated the involvement of p63 and p73 in female reproduction and their roles in egg formation and apoptosis (p63) and spindle checkpoint (p73) in female mice. Here, the role of p63 and p73 in human reproduction was investigated. Selected alleles of SNPs in p63 and p73 genes were enriched in IVF patients. These findings demonstrate that the p53 family members are involved in several steps to regulate female reproduction in mice and humans.

Mendeley readers

The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Poland 1 2%
Unknown 42 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 12 27%
Researcher 9 20%
Student > Master 6 14%
Student > Doctoral Student 3 7%
Other 3 7%
Other 5 11%
Unknown 6 14%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 14 32%
Agricultural and Biological Sciences 11 25%
Medicine and Dentistry 5 11%
Computer Science 1 2%
Earth and Planetary Sciences 1 2%
Other 2 5%
Unknown 10 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 February 2015.
All research outputs
#7,736,277
of 12,371,167 outputs
Outputs from FASEB Journal
#4,421
of 5,715 outputs
Outputs of similar age
#139,277
of 267,728 outputs
Outputs of similar age from FASEB Journal
#40
of 72 outputs
Altmetric has tracked 12,371,167 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,715 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.5. This one is in the 16th percentile – i.e., 16% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 267,728 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 72 others from the same source and published within six weeks on either side of this one. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.