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Cadherin-related Family Member 3 Genetics and Rhinovirus C Respiratory Illnesses

Overview of attention for article published in American Journal of Respiratory & Critical Care Medicine, March 2018
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (63rd percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

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5 tweeters
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1 research highlight platform

Citations

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37 Dimensions

Readers on

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19 Mendeley
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Title
Cadherin-related Family Member 3 Genetics and Rhinovirus C Respiratory Illnesses
Published in
American Journal of Respiratory & Critical Care Medicine, March 2018
DOI 10.1164/rccm.201705-1021oc
Pubmed ID
Authors

Klaus Bønnelykke, Amaziah T. Coleman, Michael D. Evans, Jonathan Thorsen, Johannes Waage, Nadja H. Vissing, Christian J. Carlsson, Jakob Stokholm, Bo L. Chawes, Leon E. Jessen, Thea K. Fischer, Yury A. Bochkov, Carole Ober, Robert F. Lemanske, Daniel J. Jackson, James E. Gern, Hans Bisgaard

Abstract

Background Experimental evidence suggests that CDHR3 is a receptor for rhinovirus-C (RV-C), and a missense variant in this gene (rs6967330) is associated with childhood asthma with severe exacerbations. Objective To determine whether rs6967330 influences RV-C infections and illnesses in early childhood. Methods We studied associations between rs6967330 and respiratory infections and illnesses in the COPSAC2010 and COAST birth cohorts, where respiratory infections were monitored prospectively for the first 3 years of life. Nasal samples were collected during acute infections in both cohorts and during asymptomatic periods in COAST and analyzed for RV-A, RV-B and RV-C, and other common respiratory viruses. Results The CDHR3 asthma risk-allele (rs6967330-A) was associated with increased risk of respiratory tract illnesses (IRR 1.14 [1.05-1.23], P=0.003). Particularly, this variant was associated with risk of respiratory episodes with detection of RV-C in COPSAC2010 (IRR 1.89 [1.14-3.05], P=0.01) and in COAST (IRR 1.37 [1.02-1.82], P=0.03) children, and in a combined meta-analysis (IRR 1.51 [1.13-2.02], P=0.006). In contrast, the variant was not associated with illnesses related to other viruses (IRR 1.07 [0.92-1.25], P=0.37). Consistent with these observations, the CDHR3 variant was associated with increased detection of RV-C but not of other viruses during scheduled visits at specific ages. Conclusion The CDHR3 asthma risk allele is associated specifically with RV-C illnesses in two birth cohorts. This clinical evidence supports earlier molecular evidence indicating that CDHR3 functions as an RV-C receptor, and raises the possibility of preventing RV-C infections by targeting CDHR3.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 19 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 37%
Researcher 3 16%
Professor 2 11%
Other 1 5%
Student > Bachelor 1 5%
Other 2 11%
Unknown 3 16%
Readers by discipline Count As %
Medicine and Dentistry 10 53%
Biochemistry, Genetics and Molecular Biology 4 21%
Immunology and Microbiology 1 5%
Unknown 4 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 March 2019.
All research outputs
#4,218,847
of 14,460,564 outputs
Outputs from American Journal of Respiratory & Critical Care Medicine
#3,645
of 7,769 outputs
Outputs of similar age
#100,039
of 275,732 outputs
Outputs of similar age from American Journal of Respiratory & Critical Care Medicine
#88
of 152 outputs
Altmetric has tracked 14,460,564 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 7,769 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.1. This one has gotten more attention than average, scoring higher than 52% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 275,732 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.
We're also able to compare this research output to 152 others from the same source and published within six weeks on either side of this one. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.