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X Demographics
Mendeley readers
Attention Score in Context
| Title |
IL-7 and CCL19 expression in CAR-T cells improves immune cell infiltration and CAR-T cell survival in the tumor
|
|---|---|
| Published in |
Nature Biotechnology, March 2018
|
| DOI | 10.1038/nbt.4086 |
| Pubmed ID | |
| Authors |
Keishi Adachi, Yosuke Kano, Tomohiko Nagai, Namiko Okuyama, Yukimi Sakoda, Koji Tamada |
| Abstract |
Infiltration, accumulation, and survival of chimeric antigen receptor T (CAR-T) cells in solid tumors is crucial for tumor clearance. We engineered CAR-T cells to express interleukin (IL)-7 and CCL19 (7 × 19 CAR-T cells), as these factors are essential for the maintenance of T-cell zones in lymphoid organs. In mice, 7 × 19 CAR-T cells achieved complete regression of pre-established solid tumors and prolonged mouse survival, with superior anti-tumor activity compared to conventional CAR-T cells. Histopathological analyses showed increased infiltration of dendritic cells (DC) and T cells into tumor tissues following 7 × 19 CAR-T cell therapy. Depletion of recipient T cells before 7 × 19 CAR-T cell administration dampened the therapeutic effects of 7 × 19 CAR-T cell treatment, suggesting that CAR-T cells and recipient immune cells collaborated to exert anti-tumor activity. Following treatment of mice with 7 × 19 CAR-T cells, both recipient conventional T cells and administered CAR-T cells generated memory responses against tumors. |
X Demographics
The data shown below were collected from the profiles of 124 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 45 | 36% |
| Japan | 7 | 6% |
| United Kingdom | 5 | 4% |
| Spain | 4 | 3% |
| France | 3 | 2% |
| China | 3 | 2% |
| Turkey | 1 | <1% |
| Sweden | 1 | <1% |
| Iraq | 1 | <1% |
| Other | 7 | 6% |
| Unknown | 47 | 38% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 93 | 75% |
| Scientists | 18 | 15% |
| Practitioners (doctors, other healthcare professionals) | 8 | 6% |
| Science communicators (journalists, bloggers, editors) | 5 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 677 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 677 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 137 | 20% |
| Student > Ph. D. Student | 114 | 17% |
| Student > Bachelor | 55 | 8% |
| Other | 43 | 6% |
| Student > Master | 42 | 6% |
| Other | 91 | 13% |
| Unknown | 195 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 141 | 21% |
| Immunology and Microbiology | 101 | 15% |
| Agricultural and Biological Sciences | 74 | 11% |
| Medicine and Dentistry | 69 | 10% |
| Engineering | 23 | 3% |
| Other | 64 | 9% |
| Unknown | 205 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 136. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 February 2024.
All research outputs
#310,416
of 25,734,859 outputs
Outputs from Nature Biotechnology
#714
of 8,610 outputs
Outputs of similar age
#7,058
of 348,395 outputs
Outputs of similar age from Nature Biotechnology
#20
of 75 outputs
Altmetric has tracked 25,734,859 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 8,610 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 44.4. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 348,395 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 75 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.