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The Role of Oncogenic Tyrosine Kinase NPM-ALK in Genomic Instability

Overview of attention for article published in Cancers, March 2018
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (69th percentile)
  • High Attention Score compared to outputs of the same age and source (84th percentile)

Mentioned by

twitter
6 tweeters
peer_reviews
1 peer review site

Citations

dimensions_citation
1 Dimensions

Readers on

mendeley
16 Mendeley
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Title
The Role of Oncogenic Tyrosine Kinase NPM-ALK in Genomic Instability
Published in
Cancers, March 2018
DOI 10.3390/cancers10030064
Pubmed ID
Authors

Cosimo Lobello, Vasilis Bikos, Andrea Janikova, Sarka Pospisilova

Abstract

Genomic stability is crucial for cell life and transmitting genetic material is one of the primary tasks of the cell. The cell needs to be able to recognize any possible error and quickly repair it, and thus, cells have developed several mechanisms to detect DNA damage and promote repair during evolution. The DNA damage response (DDR) and DNA repair pathways ensure the control of possible errors that could impair the duplication of genetic information and introduce variants in the DNA. Endogenous and exogenous factors compromise genomic stability and cause dysregulation in the DDR and DNA repair pathways. Cancer cells often impair these mechanisms to overcome cellular barriers (cellular senescence and/or apoptosis), leading to malignancy. NPM (nucleophosmin)-ALK (anaplastic lymphoma kinase) is an oncogenic tyrosine kinase that is involved in the development of anaplastic large cell lymphoma (ALCL). NPM-ALK is known to be involved in the activation of proliferative and anti-apoptotic signaling pathways. New evidence reveals that NPM-ALK translocation also impairs the ability of cells to maintain the genomic stability through both DDR and DNA repair pathways. This review aims to highlight the role of the oncogenic tyrosine kinase NPM-ALK in the cell, and pointing to new possible therapeutic strategies.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 16 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 38%
Student > Postgraduate 3 19%
Student > Bachelor 3 19%
Researcher 3 19%
Other 1 6%
Other 0 0%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 7 44%
Medicine and Dentistry 3 19%
Agricultural and Biological Sciences 2 13%
Veterinary Science and Veterinary Medicine 1 6%
Immunology and Microbiology 1 6%
Other 1 6%
Unknown 1 6%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 May 2018.
All research outputs
#3,087,221
of 12,892,079 outputs
Outputs from Cancers
#171
of 1,270 outputs
Outputs of similar age
#81,288
of 269,309 outputs
Outputs of similar age from Cancers
#14
of 91 outputs
Altmetric has tracked 12,892,079 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,270 research outputs from this source. They receive a mean Attention Score of 3.2. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 269,309 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.
We're also able to compare this research output to 91 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.