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New therapeutic potential of microRNA treatment to target vulnerable atherosclerotic lesions and plaque rupture

Overview of attention for article published in Current opinion in cardiology, November 2011
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1 tweeter

Citations

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Title
New therapeutic potential of microRNA treatment to target vulnerable atherosclerotic lesions and plaque rupture
Published in
Current opinion in cardiology, November 2011
DOI 10.1097/hco.0b013e32834b7f95
Pubmed ID
Authors

Kenneth Martin, John F. O'Sullivan, Noel M. Caplice

Abstract

Atherosclerotic lesion vulnerability leading to plaque rupture is a major cause of morbidity in western society. Although several recent major trials have identified statins and angiotensin-converting enzyme inhibitors as having a pleiotropic benefit, no current therapeutic regime directly targets atherosclerosis. The emerging functions of microRNAs (miRs) in regulating gene expression have opened diverse possibilities in understanding plaque biology and in offering new therapeutic strategies. In this review, we consider vascular endothelial cells, smooth muscle cells and monocytes as the main cellular participants in vessel homeostasis during atherosclerosis evolution and discuss how they are functionally modified by miRs and how these modifications may allow therapeutic targeting.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 5%
Unknown 19 95%

Demographic breakdown

Readers by professional status Count As %
Student > Master 4 20%
Researcher 4 20%
Student > Doctoral Student 3 15%
Student > Ph. D. Student 3 15%
Other 1 5%
Other 2 10%
Unknown 3 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 7 35%
Biochemistry, Genetics and Molecular Biology 4 20%
Medicine and Dentistry 3 15%
Nursing and Health Professions 1 5%
Immunology and Microbiology 1 5%
Other 1 5%
Unknown 3 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 September 2011.
All research outputs
#9,876,998
of 12,365,836 outputs
Outputs from Current opinion in cardiology
#480
of 991 outputs
Outputs of similar age
#61,700
of 78,404 outputs
Outputs of similar age from Current opinion in cardiology
#7
of 9 outputs
Altmetric has tracked 12,365,836 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 991 research outputs from this source. They receive a mean Attention Score of 2.1. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 78,404 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 10th percentile – i.e., 10% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.