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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Effect of the crude extract of Eugenia uniflora in morphogenesis and secretion of hydrolytic enzymes in Candida albicans from the oral cavity of kidney transplant recipients
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|---|---|
| Published in |
BMC Complementary Medicine and Therapies, February 2015
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| DOI | 10.1186/s12906-015-0522-x |
| Pubmed ID | |
| Authors |
Walicyranison Plinio Silva-Rocha, Vitor Luiz de Brito Lemos, Magda Rhayanny Assunção Ferreira, Luiz Alberto Lira Soares, Terezinha Inês Estivalet Svidzisnki, Eveline Pipolo Milan, Guilherme Maranhão Chaves |
| Abstract |
Background Candida albicans is a diploid yeast that in some circumstances may cause oral or oropharyngeal infections. Yeasts virulence factors contribute for both the maintenance of colonizing strains in addition to damage and cause tissue invasion, thus the establishment of infection occurs. The limited arsenal of antifungal drugs for the treatment of candidiasis turn the investigation of natural products mandatory for the discovery of new targets for antifungal drug development. Therefore, tropical countries emerge as important providers of natural products with potential antimicrobial activity. This study aimed to investigate morphogenesis and secretion of hydrolytic enzymes (phospholipase and proteinase) in the presence of the CE of Eugenia uniflora.MethodsThe isolates were tested for their ability to form hyphae in both solid and liquid media under three different conditions: YPD¿+¿20% FBS, Spider medium and GlcNac and the ability to secrete phospholipase and proteinase in the presence of 2000 ¿g/mL of E. uniflora.ResultsThe CE of E. uniflora inhibited hypha formation in both liquid and solid media tested. It also impaired hydrolytic enzymes production.ConclusionsThis was the first study to describe the interaction of a natural product with the full expression of three different factors in C. albicans. E. uniflora may be an alternative therapeutic for oral candidiasis in the future. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 82 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Indonesia | 1 | 1% |
| Unknown | 81 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 16 | 20% |
| Student > Master | 9 | 11% |
| Student > Ph. D. Student | 8 | 10% |
| Student > Doctoral Student | 7 | 9% |
| Researcher | 5 | 6% |
| Other | 10 | 12% |
| Unknown | 27 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 16 | 20% |
| Pharmacology, Toxicology and Pharmaceutical Science | 8 | 10% |
| Immunology and Microbiology | 8 | 10% |
| Agricultural and Biological Sciences | 7 | 9% |
| Biochemistry, Genetics and Molecular Biology | 5 | 6% |
| Other | 5 | 6% |
| Unknown | 33 | 40% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 February 2015.
All research outputs
#15,936,621
of 23,656,895 outputs
Outputs from BMC Complementary Medicine and Therapies
#2,072
of 3,711 outputs
Outputs of similar age
#214,084
of 355,487 outputs
Outputs of similar age from BMC Complementary Medicine and Therapies
#33
of 53 outputs
Altmetric has tracked 23,656,895 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,711 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.1. This one is in the 35th percentile – i.e., 35% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 355,487 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 53 others from the same source and published within six weeks on either side of this one. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.