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Clinical significance and prognostic value of receptor conversion in hormone receptor positive breast cancers after neoadjuvant chemotherapy

Overview of attention for article published in World Journal of Surgical Oncology, March 2018
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (63rd percentile)

Mentioned by

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1 policy source
twitter
1 tweeter

Citations

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3 Dimensions

Readers on

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15 Mendeley
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Title
Clinical significance and prognostic value of receptor conversion in hormone receptor positive breast cancers after neoadjuvant chemotherapy
Published in
World Journal of Surgical Oncology, March 2018
DOI 10.1186/s12957-018-1332-7
Pubmed ID
Authors

Libo Yang, Xiaorong Zhong, Tianjie Pu, Yan Qiu, Feng Ye, Hong Bu

Abstract

Neoadjuvant chemotherapy (NAC) is widely used in advanced breast cancer patients. However, there is little known about conversion frequency of estrogen receptor (ER) and/or progesterone receptor (PR) status for hormone receptor positive-breast cancer patients after NAC and their correlation with prognosis. In this study, 231 breast cancer patients with residual disease after NAC were enrolled and divided into receptor stable group (having no conversion in both ER and PR status pre- and post-NAC) and any receptor conversion group (having any conversion in either ER or PR status). Univariate and multivariate survival analyses were used to compare survival differences between the two groups. Fifty-five patients (23.8%) had ER and/or PR conversion after NAC. Younger patients (≤ 50 years) were more likely to have receptor conversion (P = 0.014). For 213 patients (92.2%) who received adjuvant endocrinotherapy after surgery, the 5-year disease free survival (DFS) estimates for patients in the any receptor conversion group (55.2%) was worse than patients in the receptor stable group (73.7%, Log-rank test, P = 0.015). While the 5-year overall survival estimates for patients with or without receptor conversion were not statistically different (86.0 vs. 82.4%, Log-rank test, P = 0.587). In multivariate Cox proportional hazard analyses, patients with any receptor conversion had worse DFS (hazard ratio, 1.995; 95% confidence interval, 1.130-3.521, P = 0.031). It is necessary to recommend patients to test biomarkers in residual disease and pay more attention to patients who have any receptor conversion. These patients may need more individual therapy after surgery.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 15 100%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 2 13%
Researcher 2 13%
Student > Master 2 13%
Student > Bachelor 1 7%
Professor 1 7%
Other 3 20%
Unknown 4 27%
Readers by discipline Count As %
Medicine and Dentistry 5 33%
Nursing and Health Professions 1 7%
Biochemistry, Genetics and Molecular Biology 1 7%
Physics and Astronomy 1 7%
Pharmacology, Toxicology and Pharmaceutical Science 1 7%
Other 1 7%
Unknown 5 33%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 January 2019.
All research outputs
#4,168,399
of 14,554,126 outputs
Outputs from World Journal of Surgical Oncology
#111
of 1,464 outputs
Outputs of similar age
#98,716
of 275,832 outputs
Outputs of similar age from World Journal of Surgical Oncology
#1
of 1 outputs
Altmetric has tracked 14,554,126 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 1,464 research outputs from this source. They receive a mean Attention Score of 1.8. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 275,832 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them