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The orphan nuclear receptor TLX regulates hippocampal transcriptome changes induced by IL-1β

Overview of attention for article published in Brain, Behavior & Immunity, May 2018
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Title
The orphan nuclear receptor TLX regulates hippocampal transcriptome changes induced by IL-1β
Published in
Brain, Behavior & Immunity, May 2018
DOI 10.1016/j.bbi.2018.03.006
Pubmed ID
Authors

Ciarán S. Ó'Léime, Alan E. Hoban, Cara M. Hueston, Roman Stilling, Gerard Moloney, John F. Cryan, Yvonne M. Nolan

Abstract

TLX is an orphan nuclear receptor highly expressed within neural progenitor cells (NPCs) in the hippocampus where is regulates proliferation. Inflammation has been shown to have negative effects on hippocampal function as well as on NPC proliferation. Specifically, the pro-inflammatory cytokine IL-1β has been shown to suppress NPC proliferation as well as TLX expression in the hippocampus. However, it is unknown whether TLX itself is involved in regulating the inflammatory response in the hippocampus. To explore the role of TLX in inflammation, we assessed changes in the transcriptional landscape of the hippocampus of TLX knockout mice (TLX-/-) compared to wildtype (WT) littermate controls with and without intrahippocampal injection of IL-1β using a whole transcriptome RNA sequencing approach. We demonstrated that there is an increase in the transcription of genes involved in the promotion of inflammation and regulation of cell chemotaxis (Tnf, Il1b, Cxcr1, Cxcr2, Tlr4) and a decrease in the expression of genes relating to synaptic signalling (Lypd1, Syt4, Cplx2) in cannulated TLX-/-mice compared to WT controls. We demonstrate that mice lacking in TLX share a similar increase in 176 genes involved in regulating inflammation (e.g. Cxcl1, Tnf, Il1b) as WT mice injected with IL-1β into the hippocampus. Moreover, TLX-/-mice injected with IL-1β display a blunted transcriptional profile compared to WT mice injected with IL-1β. Thus, TLX-/-mice, which already have an exaggerated inflammatory profile after cannulation surgery, are primed to respond differently to an inflammatory stimulus such as IL-1β. Together, these results demonstrate that TLX regulates hippocampal inflammatory transcriptome response to brain injury (in this case cannulation surgery) and cytokine stimulation.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 29 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 31%
Student > Bachelor 4 14%
Student > Master 3 10%
Student > Ph. D. Student 3 10%
Student > Doctoral Student 2 7%
Other 4 14%
Unknown 4 14%
Readers by discipline Count As %
Neuroscience 8 28%
Medicine and Dentistry 4 14%
Agricultural and Biological Sciences 4 14%
Biochemistry, Genetics and Molecular Biology 3 10%
Pharmacology, Toxicology and Pharmaceutical Science 1 3%
Other 1 3%
Unknown 8 28%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 May 2019.
All research outputs
#9,239,758
of 15,094,232 outputs
Outputs from Brain, Behavior & Immunity
#1,489
of 2,304 outputs
Outputs of similar age
#155,909
of 278,142 outputs
Outputs of similar age from Brain, Behavior & Immunity
#32
of 63 outputs
Altmetric has tracked 15,094,232 research outputs across all sources so far. This one is in the 36th percentile – i.e., 36% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,304 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.7. This one is in the 31st percentile – i.e., 31% of its peers scored the same or lower than it.
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We're also able to compare this research output to 63 others from the same source and published within six weeks on either side of this one. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.