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MicroRNA-146a and microRNA-155 as novel crevicular fluid biomarkers for periodontitis in non-diabetic and type 2 diabetic patients

Overview of attention for article published in Journal of Clinical Periodontology, May 2018
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2 tweeters

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49 Mendeley
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Title
MicroRNA-146a and microRNA-155 as novel crevicular fluid biomarkers for periodontitis in non-diabetic and type 2 diabetic patients
Published in
Journal of Clinical Periodontology, May 2018
DOI 10.1111/jcpe.12888
Pubmed ID
Authors

Nikola Radović, Nataša Nikolić Jakoba, Nina Petrović, Aleksandra Milosavljević, Božidar Brković, Jelena Roganović

Abstract

Recent studies point at the crucial role of epigenetic mechanisms in the development of multifactorial diseases such as periodontitis and diabetes mellitus (DM) type 2. In addition, circulatory microRNAs (miRs) have emerged as novel biomarkers for various diseases. Aim of this study was to investigate the levels of miR-146a and miR-155 and superoxide dismutase (SOD) activity in gingival crevicular fluid (GCF) of periodontitis patients with (CPDM) and without (CP) DM type 2 as well as in periodontally healthy, control groups (PHDM and PH, respectively). miR modulation was analyzed using quantitative real-time PCR while SOD activity was measured spectrophotometrically. The upregulation of miR-146a and miR-155 was observed in CP andCPDM patients baseline while the levels decreased after six weeks of the non-surgical therapy to the levels comparable to PH and PHDM, respectively. Expression levels of miRs positively correlated with SOD activity. Levels of miR-146a were higher in PHDM compared to PH patients. Multivariate analysis revealed that levels of miR-146a and miR-155 were significantly associated with periodontitis when adjusting for age and gender. miR-146a and miR-155 may be consider as possible novel biomarkers for periodontitis in nondiabetic and type 2 diabetic patients. This article is protected by copyright. All rights reserved.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 49 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 14%
Student > Master 6 12%
Student > Doctoral Student 5 10%
Student > Postgraduate 4 8%
Student > Bachelor 4 8%
Other 11 22%
Unknown 12 24%
Readers by discipline Count As %
Medicine and Dentistry 28 57%
Biochemistry, Genetics and Molecular Biology 4 8%
Nursing and Health Professions 2 4%
Social Sciences 1 2%
Agricultural and Biological Sciences 1 2%
Other 0 0%
Unknown 13 27%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 March 2018.
All research outputs
#10,504,009
of 13,791,430 outputs
Outputs from Journal of Clinical Periodontology
#1,180
of 1,460 outputs
Outputs of similar age
#189,483
of 273,871 outputs
Outputs of similar age from Journal of Clinical Periodontology
#9
of 17 outputs
Altmetric has tracked 13,791,430 research outputs across all sources so far. This one is in the 20th percentile – i.e., 20% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,460 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.9. This one is in the 16th percentile – i.e., 16% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 273,871 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.