Chapter title |
Amyloid PET Imaging: Standardization and Integration with Other Alzheimer’s Disease Biomarkers
|
---|---|
Chapter number | 13 |
Book title |
Biomarkers for Alzheimer’s Disease Drug Development
|
Published in |
Methods in molecular biology, January 2018
|
DOI | 10.1007/978-1-4939-7704-8_13 |
Pubmed ID | |
Book ISBNs |
978-1-4939-7703-1, 978-1-4939-7704-8
|
Authors |
Silvia Morbelli, Matteo Bauckneht |
Abstract |
Amyloid plaques are a neuropathologic hallmark of Alzheimer's disease (AD), which can be imaged through positron emission tomography (PET) technology using radiopharmaceuticals that selectively bind to the fibrillar aggregates of amyloid-β plaques (Amy-PET). Several radiotracers for amyloid PET have been investigated, including11C-Pittsburgh compound B and the18F-labeled compounds such as18F-florbetaben,18F-florbetapir, and18F-flutemetamol. Besides the injected radiotracer, images can be interpreted by means of visual/qualitative, semiquantitative, and quantitative criteria. Here we summarize the main differences between the available radiotracers for Amy-PET, the proposed interpretation criteria, and analytical methods. |
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