| Chapter title |
Neuroimaging Methods for MRI Analysis in CSF Biomarkers Studies
|
|---|---|
| Chapter number | 11 |
| Book title |
Biomarkers for Alzheimer’s Disease Drug Development
|
| Published in |
Methods in molecular biology, January 2018
|
| DOI | 10.1007/978-1-4939-7704-8_11 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-7703-1, 978-1-4939-7704-8
|
| Authors |
Carles Falcon, Grégory Operto, José Luis Molinuevo, Juan Domingo Gispert |
| Abstract |
Among others, the existence of pathophysiological biomarkers such as cerebrospinal fluid (CSF) Aβ-42, t-tau, and p-tau preceding the onset of Alzheimer's disease (AD) symptomatology have shifted the conceptualization of AD as a continuum. In addition, magnetic resonance imaging (MRI) enables the study of structural and functional cross-sectional correlates and longitudinal changes in vivo and, therefore, the combination of CSF data and imaging analyses emerges as a synergistic approach to understand the structural correlates related with specific AD-related biomarkers. In this chapter, we describe the methods used in neuroimaging that will allow researchers to combine data on CSF metabolites with imaging analyses. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 11 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 4 | 36% |
| Student > Bachelor | 1 | 9% |
| Lecturer > Senior Lecturer | 1 | 9% |
| Student > Master | 1 | 9% |
| Student > Ph. D. Student | 1 | 9% |
| Other | 0 | 0% |
| Unknown | 3 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 3 | 27% |
| Linguistics | 1 | 9% |
| Sports and Recreations | 1 | 9% |
| Psychology | 1 | 9% |
| Unknown | 5 | 45% |