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Biomarkers for Alzheimer’s Disease Drug Development

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Cover of 'Biomarkers for Alzheimer’s Disease Drug Development'

Table of Contents

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    Book Overview
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    Chapter 1 Epidemiology of Dementia: The Burden on Society, the Challenges for Research
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    Chapter 2 Population-Based Approaches to Alzheimer’s Disease Prevention
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    Chapter 3 Systems Biology Methods for Alzheimer’s Disease Research Toward Molecular Signatures, Subtypes, and Stages and Precision Medicine: Application in Cohort Studies and Trials
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    Chapter 4 CSF Lipidomics Analysis: High-Resolution Mass Spectrometry Analytical Platform
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    Chapter 5 CSF N-Glycomics Using MALDI MS Techniques in Alzheimer’s Disease
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    Chapter 6 MicroRNA Profiling of Alzheimer’s Disease Cerebrospinal Fluid
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    Chapter 7 Validation of a Chemiluminescence Immunoassay for Measuring Amyloid-β in Human Blood Plasma
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    Chapter 8 Mass Spectrometry-Based Metabolomic Multiplatform for Alzheimer’s Disease Research
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    Chapter 9 Blood-Based Biomarker Screening with Agnostic Biological Definitions for an Accurate Diagnosis Within the Dimensional Spectrum of Neurodegenerative Diseases
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    Chapter 10 Functional Magnetic Resonance Imaging in Alzheimer’ Disease Drug Development
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    Chapter 11 Neuroimaging Methods for MRI Analysis in CSF Biomarkers Studies
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    Chapter 12 Hybrid PET-MRI in Alzheimer’s Disease Research
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    Chapter 13 Amyloid PET Imaging: Standardization and Integration with Other Alzheimer’s Disease Biomarkers
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    Chapter 14 The Use of 18F-FDG PET in the Diagnostic Workup of Alzheimer’s Dementia
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    Chapter 15 Quantification of Tau Load in Alzheimer’s Disease Clinical Trials Using Positron Emission Tomography
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    Chapter 16 Imaging Neuroinflammation: Quantification of Astrocytosis in a Multitracer PET Approach
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    Chapter 17 Unbiased Lipidomics and Metabolomics of Human Brain Samples
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    Chapter 18 Neuropathological Assessment as an Endpoint in Clinical Trial Design
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    Chapter 19 Analysis of Micro-RNA Expression by qPCR on a Microfluidics Platform for Alzheimer’s Disease Biomarker Discovery
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    Chapter 20 Telomere Length Shortening in Alzheimer’s Disease: Procedures for a Causal Investigation Using Single Nucleotide Polymorphisms in a Mendelian Randomization Study
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    Chapter 21 Quantifying miRNA Deregulation in Alzheimer’s Disease
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    Chapter 22 Imaging of Microglial Activation in Alzheimer’s Disease by [11C]PBR28 PET
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    Chapter 23 In Vivo Two-Photon Calcium Imaging of Hippocampal Neurons in Alzheimer Mouse Models
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    Chapter 24 Cognitive Assessment in Alzheimer’s Disease Clinical Trials
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    Chapter 25 Data Mining and Machine Learning Methods for Dementia Research
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