Title |
Intasome architecture and chromatin density modulate retroviral integration into nucleosome
|
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Published in |
Retrovirology, February 2015
|
DOI | 10.1186/s12977-015-0145-9 |
Pubmed ID | |
Authors |
Mohamed Salah Benleulmi, Julien Matysiak, Daniel Rodrigo Henriquez, Cédric Vaillant, Paul Lesbats, Christina Calmels, Monica Naughtin, Oscar Leon, Anna Marie Skalka, Marc Ruff, Marc Lavigne, Marie-Line Andreola, Vincent Parissi |
Abstract |
Retroviral integration depends on the interaction between intasomes, host chromatin and cellular targeting cofactors as LEDGF/p75 or BET proteins. Previous studies indicated that the retroviral integrase, by itself, may play a role in the local integration site selection within nucleosomal target DNA. We focused our study on this local association by analyzing the intrinsic properties of various retroviral intasomes to functionally accommodate different chromatin structures in the lack of other cofactors. |
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