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Inflammation and Nitrosative Stress Effects in Ovarian and Prostate Pathology and Carcinogenesis

Overview of attention for article published in Antioxidants & Redox Signaling, March 2017
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Mentioned by

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2 tweeters

Citations

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17 Dimensions

Readers on

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10 Mendeley
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Title
Inflammation and Nitrosative Stress Effects in Ovarian and Prostate Pathology and Carcinogenesis
Published in
Antioxidants & Redox Signaling, March 2017
DOI 10.1089/ars.2017.7004
Pubmed ID
Authors

Burke, Amy J., Garrido, Pablo, Johnson, Carol, Sullivan, Francis J., Glynn, Sharon A.

Abstract

Prostate and ovarian cancers are major contributors to cancer-related deaths worldwide. Recently, inflammation and nitrosative stress have been implicated in carcinogenesis, with the overexpression of NOS2 and concomitant release of nitric oxide (NO) associated with cancer initiation and progression. Recent Advances: An increasing body of evidence indicates an association between NOS2 expression and aggressive ovarian cancer. Research also indicates a role for NO in prostate disease pathology and prostate cancer. A therapeutic role for NOS2 inhibition and/or NO drugs exists for the treatment of both ovarian and prostate tumors. Herein, we review the key molecular effects associated with NOS2 in ovarian and prostate cancer. NOS2 increases angiogenesis and tumor proliferation and correlates with aggressive type II ovarian tumors. NOS2 expressing tumors are sensitive to cisplatin chemotherapy, and NO may be used to sensitize cisplatin-resistant tumors to chemotherapy. NOS2 is highly expressed in prostate tumors compared to non-neoplastic prostate pathologies. NO may play a role in the development of androgen-independent prostate cancer via s-nitrosylation of the androgen receptor. Moreover, NOS2 inhibitors and NO donor drugs show therapeutic potential in ovarian and prostate cancer as single agents or dual drugs, by either inhibiting the effects of NOS2 or increasing NO levels to induce cytotoxic effects. NOS2 and NO present new targets for the treatment of ovarian and prostate tumors. Furthermore, understanding NO-related tumor biology in these cancers presents a new means for improved patient stratification to the appropriate treatment regimen. Antioxid. Redox Signal. 00, 000-000.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 10 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 2 20%
Student > Master 2 20%
Student > Ph. D. Student 1 10%
Researcher 1 10%
Professor > Associate Professor 1 10%
Other 0 0%
Unknown 3 30%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 2 20%
Medicine and Dentistry 1 10%
Computer Science 1 10%
Neuroscience 1 10%
Chemistry 1 10%
Other 0 0%
Unknown 4 40%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 March 2018.
All research outputs
#13,596,382
of 17,714,352 outputs
Outputs from Antioxidants & Redox Signaling
#1,143
of 1,619 outputs
Outputs of similar age
#200,816
of 286,688 outputs
Outputs of similar age from Antioxidants & Redox Signaling
#13
of 21 outputs
Altmetric has tracked 17,714,352 research outputs across all sources so far. This one is in the 20th percentile – i.e., 20% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,619 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one is in the 25th percentile – i.e., 25% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 286,688 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 24th percentile – i.e., 24% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.