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Relationship between hypertension and periapical lesion: an in vitro and in vivo study

Overview of attention for article published in Brazilian Oral Research, January 2016
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Relationship between hypertension and periapical lesion: an in vitro and in vivo study
Published in
Brazilian Oral Research, January 2016
DOI 10.1590/1807-3107bor-2016.vol30.0078
Pubmed ID

Christine Men MARTINS, Hajime SASAKI, Kimito HIRAI, Ana Cristina ANDRADA, João Eduardo GOMES-FILHO


The aim of this study was to compare potential aspects of periapical lesion formation in hypertensive and normotensive conditions using hypertensive (BPH/2J) and wild-type control (BPN/3J) mice. The mandibular first molars of both strains had their dental pulp exposed. At day 21 the mice were euthanized and right mandibular molars were used to evaluate the size and phenotype of apical periodontitis by microCT. Proteins were extracted from periapical lesion on the left side and the expressions of IL1α, IL1β and TNFα were analyzed by ELISA. Bone marrow stem cells were isolated from adult mice femurs from 2 strains and osteoclast differentiation was evaluated by tartrate-resistant acid phosphatase (TRAP) in vitro. The amount of differentiated osteoclastic cells was nearly double in hypertensive mice when compared to the normotensive strain (p < 0.03). Periapical lesion size did not differ between hypertensive and normotensive strains (p > 0.7). IL1α, IL1β and TNFα cytokines expressions were similar for both systemic conditions (p > 0.05). Despite the fact that no differences could be observed in periapical lesion size and cytokines expressions on the systemic conditions tested, hypertension showed an elevated number of osteoclast differentiation.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 68 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 68 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 12%
Student > Bachelor 8 12%
Student > Master 7 10%
Student > Postgraduate 6 9%
Student > Doctoral Student 4 6%
Other 17 25%
Unknown 18 26%
Readers by discipline Count As %
Medicine and Dentistry 36 53%
Arts and Humanities 2 3%
Agricultural and Biological Sciences 2 3%
Biochemistry, Genetics and Molecular Biology 2 3%
Pharmacology, Toxicology and Pharmaceutical Science 1 1%
Other 6 9%
Unknown 19 28%