Chapter title |
Using Molecular Tweezers to Remodel Abnormal Protein Self-Assembly and Inhibit the Toxicity of Amyloidogenic Proteins
|
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Chapter number | 24 |
Book title |
Peptide Self-Assembly
|
Published in |
Methods in molecular biology, January 2018
|
DOI | 10.1007/978-1-4939-7811-3_24 |
Pubmed ID | |
Book ISBNs |
978-1-4939-7809-0, 978-1-4939-7811-3
|
Authors |
Ravinder Malik, Jing Di, Gayatri Nair, Aida Attar, Karen Taylor, Edmond Teng, Frank-Gerrit Klärner, Thomas Schrader, Gal Bitan, Malik, Ravinder, Di, Jing, Nair, Gayatri, Attar, Aida, Taylor, Karen, Teng, Edmond, Klärner, Frank-Gerrit, Schrader, Thomas, Bitan, Gal |
Abstract |
Molecular tweezers (MTs) are broad-spectrum inhibitors of abnormal protein self-assembly, which act by binding selectively to lysine and arginine residues. Through this unique mechanism of action, MTs inhibit formation of toxic oligomers and aggregates. Their efficacy and safety have been demonstrated in vitro, in cell culture, and in animal models. Here, we discuss the application of MTs in diverse in vitro and in vivo systems, the experimental details, the scope of their use, and the limitations of the approach. We also consider methods for administration of MTs in animal models to measure efficacy, pharmacokinetic, and pharmacodynamic parameters in proteinopathies. |
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