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Circular DNA elements of chromosomal origin are common in healthy human somatic tissue

Overview of attention for article published in Nature Communications, March 2018
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (96th percentile)
  • Good Attention Score compared to outputs of the same age and source (78th percentile)

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Title
Circular DNA elements of chromosomal origin are common in healthy human somatic tissue
Published in
Nature Communications, March 2018
DOI 10.1038/s41467-018-03369-8
Pubmed ID
Authors

Henrik Devitt Møller, Marghoob Mohiyuddin, Iñigo Prada-Luengo, M. Reza Sailani, Jens Frey Halling, Peter Plomgaard, Lasse Maretty, Anders Johannes Hansen, Michael P. Snyder, Henriette Pilegaard, Hugo Y. K. Lam, Birgitte Regenberg

Abstract

The human genome is generally organized into stable chromosomes, and only tumor cells are known to accumulate kilobase (kb)-sized extrachromosomal circular DNA elements (eccDNAs). However, it must be expected that kb eccDNAs exist in normal cells as a result of mutations. Here, we purify and sequence eccDNAs from muscle and blood samples from 16 healthy men, detecting ~100,000 unique eccDNA types from 16 million nuclei. Half of these structures carry genes or gene fragments and the majority are smaller than 25 kb. Transcription from eccDNAs suggests that eccDNAs reside in nuclei and recurrence of certain eccDNAs in several individuals implies DNA circularization hotspots. Gene-rich chromosomes contribute to more eccDNAs per megabase and the most transcribed protein-coding gene in muscle, TTN (titin), provides the most eccDNAs per gene. Thus, somatic genomes are rich in chromosome-derived eccDNAs that may influence phenotypes through altered gene copy numbers and transcription of full-length or truncated genes.

X Demographics

X Demographics

The data shown below were collected from the profiles of 34 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 312 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 312 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 58 19%
Researcher 52 17%
Student > Bachelor 39 13%
Student > Master 36 12%
Student > Doctoral Student 12 4%
Other 34 11%
Unknown 81 26%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 121 39%
Agricultural and Biological Sciences 51 16%
Medicine and Dentistry 19 6%
Computer Science 6 2%
Engineering 5 2%
Other 23 7%
Unknown 87 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 73. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 December 2022.
All research outputs
#575,962
of 25,220,525 outputs
Outputs from Nature Communications
#9,913
of 55,790 outputs
Outputs of similar age
#13,274
of 339,846 outputs
Outputs of similar age from Nature Communications
#270
of 1,224 outputs
Altmetric has tracked 25,220,525 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 55,790 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.8. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 339,846 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 1,224 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.