Title |
Efficacy of a quadruple therapy regimen for Helicobacter pylori eradication after partial gastrectomy
|
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Published in |
Brazilian Journal of Medical and Biological Research, February 2016
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DOI | 10.1590/1414-431x20155080 |
Pubmed ID | |
Authors |
F. Zhang, Z.J. Bao, D.M. Shi, P. Xiang, L. Xiao, Y.Q. Huang, G.S. Zhang, S.M. Yin |
Abstract |
We aimed to evaluate the effectiveness and safety of bismuth-containing quadruple therapy plus postural change after dosing for Helicobacter pylori eradication in gastrectomized patients. We compared 76 gastric stump patients with H. pylori infection (GS group) with 50 non-gastrectomized H. pylori-positive patients who met the treatment indication (controls). The GS group was divided into GS group 1 and GS group 2. All groups were administered bismuth potassium citrate (220 mg), esomeprazole (20 mg), amoxicillin (1.0 g), and furazolidone (100 mg) twice daily for 14 days. GS group 1 maintained a left lateral horizontal position for 30 min after dosing. H. pylori was detected using rapid urease testing and histologic examination of gastric mucosa before and 3 months after therapy. Mucosal histologic manifestations were evaluated using visual analog scales of the updated Sydney System. GS group 1 had a higher prevalence of eradication than the GS group 2 (intention-to-treat [ITT]: P=0.025; per-protocol [PP]: P=0.030), and the control group had a similar prevalence. GS group 2 had a lower prevalence of eradication than controls (ITT: P=0.006; PP: P=0.626). Scores for chronic inflammation and activity declined significantly (P<0.001) 3 months after treatment, whereas those for atrophy and intestinal metaplasia showed no significant change. Prevalence of adverse reactions was similar among groups during therapy (P=0.939). A bismuth-containing quadruple therapy regimen plus postural change after dosing appears to be a relatively safe, effective, economical, and practical method for H. pylori eradication in gastrectomized patients. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 33 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 7 | 21% |
Student > Master | 6 | 18% |
Researcher | 4 | 12% |
Student > Ph. D. Student | 2 | 6% |
Librarian | 1 | 3% |
Other | 3 | 9% |
Unknown | 10 | 30% |
Readers by discipline | Count | As % |
---|---|---|
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 18% |
Medicine and Dentistry | 5 | 15% |
Biochemistry, Genetics and Molecular Biology | 4 | 12% |
Nursing and Health Professions | 3 | 9% |
Agricultural and Biological Sciences | 1 | 3% |
Other | 3 | 9% |
Unknown | 11 | 33% |