↓ Skip to main content

Sphingolipids as Signaling and Regulatory Molecules

Overview of attention for book
Cover of 'Sphingolipids as Signaling and Regulatory Molecules'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 An overview of sphingolipid metabolism: from synthesis to breakdown
  3. Altmetric Badge
    Chapter 2 Sphingolipid Transport
  4. Altmetric Badge
    Chapter 3 Sphingolipid Analysis by High Performance Liquid Chromatography-Tandem Mass Spectrometry (HPLC-MS/MS)
  5. Altmetric Badge
    Chapter 4 Ceramide synthases: roles in cell physiology and signaling.
  6. Altmetric Badge
    Chapter 5 Tales and mysteries of the enigmatic sphingomyelin synthase family.
  7. Altmetric Badge
    Chapter 6 Ceramide in Stress Response
  8. Altmetric Badge
    Chapter 7 Animal models for studying the pathophysiology of ceramide.
  9. Altmetric Badge
    Chapter 8 Ceramide-1-Phosphate in Cell Survival and Inflammatory Signaling
  10. Altmetric Badge
    Chapter 9 Ceramide-1-Phosphate in Phagocytosis and Calcium Homeostasis
  11. Altmetric Badge
    Chapter 10 Extracellular and intracellular actions of sphingosine-1-phosphate.
  12. Altmetric Badge
    Chapter 11 Glucosylceramide in Humans
  13. Altmetric Badge
    Chapter 12 Gangliosides as Regulators of Cell Membrane Organization and Functions
  14. Altmetric Badge
    Chapter 13 Cancer treatment strategies targeting sphingolipid metabolism.
  15. Altmetric Badge
    Chapter 14 Therapeutic Strategies for Diabetes and Complications: A Role for Sphingolipids?
  16. Altmetric Badge
    Chapter 15 Roles for Sphingolipids in Saccharomyces cerevisiae
  17. Altmetric Badge
    Chapter 16 Sphingolipid signaling in fungal pathogens.
  18. Altmetric Badge
    Chapter 17 Sphingolipids in Parasitic Protozoa
  19. Altmetric Badge
    Chapter 18 Biosynthesis of Sphingolipids in Plants (and Some of Their Functions)
  20. Altmetric Badge
    Chapter 19 Computational analysis of sphingolipid pathway systems.
Attention for Chapter 1: An overview of sphingolipid metabolism: from synthesis to breakdown
Altmetric Badge

About this Attention Score

  • Good Attention Score compared to outputs of the same age (71st percentile)
  • High Attention Score compared to outputs of the same age and source (82nd percentile)

Mentioned by

facebook
1 Facebook page
wikipedia
2 Wikipedia pages

Citations

dimensions_citation
36 Dimensions

Readers on

mendeley
515 Mendeley
citeulike
1 CiteULike
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Chapter title
An overview of sphingolipid metabolism: from synthesis to breakdown
Chapter number 1
Book title
Sphingolipids as Signaling and Regulatory Molecules
Published in
Advances in experimental medicine and biology, February 2015
DOI 10.1007/978-1-4419-6741-1_1
Pubmed ID
Book ISBNs
978-1-4419-6740-4, 978-1-4419-6741-1
Authors

CR Gault, LM Obeid, YA Hannun, Gault CR, Obeid LM, Hannun YA, Christopher R. Gault, Lina M. Obeid, Yusuf A. Hannun

Abstract

Sphingolipids constitute a class of lipids defined by their eighteen carbon amino-alcohol backbones which are synthesized in the ER from nonsphingolipid precursors. Modification of this basic structure is what gives rise to the vast family of sphingolipids that play significant roles in membrane biology and provide many bioactive metabolites that regulate cell function. Despite the diversity of structure and function of sphingolipids, their creation and destruction are governed by common synthetic and catabolic pathways. In this regard, sphingolipid metabolism can be imagined as an array of interconnected networks that diverge from a single common entry point and converge into a single common breakdown pathway. In their simplest forms, sphingosine, phytosphingosine and dihydrosphingosine serve as the backbones upon which further complexity is achieved. For example, phosphorylation of the C1 hydroxyl group yields the final breakdown products and/or the important signaling molecules sphingosine-1-phosphate, phytosphingosine-1-phosphate and dihydrosphingosine-1-phosphate, respectively. On the other hand, acylation of sphingosine, phytosphingosine, or dihydrosphingosine with one of several possible acyl CoA molecules through the action of distinct ceramide synthases produces the molecules defined as ceramide, phytoceramide, or dihydroceramide. Ceramide, due to the differing acyl CoAs that can be used to produce it, is technically a class of molecules rather than a single molecule and therefore may have different biological functions depending on the acyl chain it is composed of. At the apex of complexity is the group of lipids known as glycosphingolipids (GSL) which contain dozens of different sphingolipid species differing by both the order and type of sugar residues attached to their headgroups. Since these molecules are produced from ceramide precursors, they too may have differences in their acyl chain composition, revealing an additional layer of variation. The glycosphingolipids are divided broadly into two categories: glucosphingolipids and galactosphingolipids. The glucosphingolipids depend initially on the enzyme glucosylceramide synthase (GCS) which attaches glucose as the first residue to the C1 hydroxyl position. Galactosphingolipids, on the other hand, are generated from galactosylceramide synthase (GalCerS), an evolutionarily dissimilar enzyme from GCS. Glycosphingolipids are further divided based upon further modification by various glycosyltransferases which increases the potential variation in lipid species by several fold. Far more abundant are the sphingomyelin species which are produced in parallel with glycosphingolipids, however they are defined by a phosphocholine headgroup rather than the addition of sugar residues. Although sphingomyelin species all share a common headgroup, they too are produced from a variety of ceramide species and therefore can have differing acyl chains attached to their C-2 amino groups. Whether or not the differing acyl chain lengths in SMs dictate unique functions or important biophysical distinctions has not yet been established. Understanding the function of all the existing glycosphingolipids and sphingomyelin species will be a major undertaking in the future since the tools to study and measure these species are only beginning to be developed (see Fig 1 for an illustrated depiction of the various sphingolipid structures). The simple sphingolipids serve both as the precursors and the breakdown products of the more complex ones. Importantly, in recent decades, these simple sphingolipids have gained attention for having significant signaling and regulatory roles within cells. In addition, many tools have emerged to measure the levels of simple sphingolipids and therefore have become the focus of even more intense study in recent years. With this thought in mind, this chapter will pay tribute to the complex sphingolipids, but focus on the regulation of simple sphingolipid metabolism.

Mendeley readers

The data shown below were compiled from readership statistics for 515 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 4 <1%
United Kingdom 3 <1%
Finland 2 <1%
United States 2 <1%
Argentina 1 <1%
Australia 1 <1%
Russia 1 <1%
Sweden 1 <1%
Unknown 500 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 146 28%
Student > Master 87 17%
Student > Bachelor 71 14%
Researcher 69 13%
Student > Doctoral Student 29 6%
Other 62 12%
Unknown 51 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 156 30%
Biochemistry, Genetics and Molecular Biology 137 27%
Chemistry 42 8%
Medicine and Dentistry 39 8%
Neuroscience 20 4%
Other 60 12%
Unknown 61 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 March 2018.
All research outputs
#3,998,791
of 13,755,747 outputs
Outputs from Advances in experimental medicine and biology
#589
of 3,275 outputs
Outputs of similar age
#76,744
of 279,963 outputs
Outputs of similar age from Advances in experimental medicine and biology
#46
of 272 outputs
Altmetric has tracked 13,755,747 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 3,275 research outputs from this source. They receive a mean Attention Score of 3.6. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 279,963 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 272 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 82% of its contemporaries.