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Structural insights into the inactivation of CRISPR-Cas systems by diverse anti-CRISPR proteins

Overview of attention for article published in BMC Biology, March 2018
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Title
Structural insights into the inactivation of CRISPR-Cas systems by diverse anti-CRISPR proteins
Published in
BMC Biology, March 2018
DOI 10.1186/s12915-018-0504-9
Pubmed ID
Authors

Yuwei Zhu, Fan Zhang, Zhiwei Huang

Abstract

A molecular arms race is progressively being unveiled between prokaryotes and viruses. Prokaryotes utilize CRISPR-mediated adaptive immune systems to kill the invading phages and mobile genetic elements, and in turn, the viruses evolve diverse anti-CRISPR proteins to fight back. The structures of several anti-CRISPR proteins have now been reported, and here we discuss their structural features, with a particular emphasis on topology, to discover their similarities and differences. We summarize the CRISPR-Cas inhibition mechanisms of these anti-CRISPR proteins in their structural context. Considering anti-CRISPRs in this way will provide important clues for studying their origin and evolution.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 98 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 98 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 19 19%
Researcher 13 13%
Student > Master 12 12%
Student > Ph. D. Student 10 10%
Other 6 6%
Other 10 10%
Unknown 28 29%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 42 43%
Agricultural and Biological Sciences 14 14%
Immunology and Microbiology 5 5%
Medicine and Dentistry 2 2%
Engineering 2 2%
Other 3 3%
Unknown 30 31%