Title |
Structural insights into the inactivation of CRISPR-Cas systems by diverse anti-CRISPR proteins
|
---|---|
Published in |
BMC Biology, March 2018
|
DOI | 10.1186/s12915-018-0504-9 |
Pubmed ID | |
Authors |
Yuwei Zhu, Fan Zhang, Zhiwei Huang |
Abstract |
A molecular arms race is progressively being unveiled between prokaryotes and viruses. Prokaryotes utilize CRISPR-mediated adaptive immune systems to kill the invading phages and mobile genetic elements, and in turn, the viruses evolve diverse anti-CRISPR proteins to fight back. The structures of several anti-CRISPR proteins have now been reported, and here we discuss their structural features, with a particular emphasis on topology, to discover their similarities and differences. We summarize the CRISPR-Cas inhibition mechanisms of these anti-CRISPR proteins in their structural context. Considering anti-CRISPRs in this way will provide important clues for studying their origin and evolution. |
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United States | 3 | 12% |
Mexico | 2 | 8% |
Australia | 1 | 4% |
Switzerland | 1 | 4% |
Italy | 1 | 4% |
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Germany | 1 | 4% |
Singapore | 1 | 4% |
Other | 0 | 0% |
Unknown | 12 | 46% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 15 | 58% |
Scientists | 7 | 27% |
Science communicators (journalists, bloggers, editors) | 3 | 12% |
Practitioners (doctors, other healthcare professionals) | 1 | 4% |
Mendeley readers
Geographical breakdown
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Unknown | 98 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 19 | 19% |
Researcher | 13 | 13% |
Student > Master | 12 | 12% |
Student > Ph. D. Student | 10 | 10% |
Other | 6 | 6% |
Other | 10 | 10% |
Unknown | 28 | 29% |
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Agricultural and Biological Sciences | 14 | 14% |
Immunology and Microbiology | 5 | 5% |
Medicine and Dentistry | 2 | 2% |
Engineering | 2 | 2% |
Other | 3 | 3% |
Unknown | 30 | 31% |