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Mendeley readers
Attention Score in Context
| Title |
The calcium-sensing receptor and related diseases
|
|---|---|
| Published in |
Arquivos Brasileiros de Endocrinologia & Metabologia, August 2006
|
| DOI | 10.1590/s0004-27302006000400008 |
| Pubmed ID | |
| Authors |
Lília D'Souza-Li |
| Abstract |
The calcium-sensing receptor (CASR) adjusts the extracellular calcium set point regulating PTH secretion and renal calcium excretion. The receptor is expressed in several tissues and is also involved in other cellular functions such as proliferation, differentiation and other hormonal secretion. High extracellular calcium levels activate the receptor resulting in modulation of several signaling pathways depending on the target tissues. Mutations in the CASR gene can result in gain or loss of receptor function. Gain of function mutations are associated to Autossomal dominant hypocalcemia and Bartter syndrome type V, while loss of function mutations are associated to Familial hypocalciuric hypercalcemia and Neonatal severe hyperparathyroidism. More than one hundred mutations were described in this gene. In addition to calcium, the receptor also interacts with several ions and polyamines. The CASR is a potential therapeutic target to treatment of diseases including hyperparathyroidism and osteoporosis, since its interaction with pharmacological compounds results in modulation of PTH secretion. |
Mendeley readers
The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 3% |
| Unknown | 32 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 10 | 30% |
| Student > Ph. D. Student | 8 | 24% |
| Student > Master | 6 | 18% |
| Professor > Associate Professor | 3 | 9% |
| Professor | 2 | 6% |
| Other | 2 | 6% |
| Unknown | 2 | 6% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 13 | 39% |
| Agricultural and Biological Sciences | 8 | 24% |
| Biochemistry, Genetics and Molecular Biology | 4 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 6% |
| Veterinary Science and Veterinary Medicine | 1 | 3% |
| Other | 3 | 9% |
| Unknown | 2 | 6% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 March 2022.
All research outputs
#4,850,861
of 23,376,718 outputs
Outputs from Arquivos Brasileiros de Endocrinologia & Metabologia
#39
of 486 outputs
Outputs of similar age
#12,199
of 66,296 outputs
Outputs of similar age from Arquivos Brasileiros de Endocrinologia & Metabologia
#2
of 8 outputs
Altmetric has tracked 23,376,718 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 486 research outputs from this source. They receive a mean Attention Score of 3.0. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 66,296 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 6 of them.