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The calcium-sensing receptor and related diseases

Overview of attention for article published in Arquivos Brasileiros de Endocrinologia & Metabologia, August 2006
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#39 of 470)
  • Good Attention Score compared to outputs of the same age (79th percentile)

Mentioned by

patent
4 patents
wikipedia
4 Wikipedia pages

Citations

dimensions_citation
52 Dimensions

Readers on

mendeley
33 Mendeley
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Title
The calcium-sensing receptor and related diseases
Published in
Arquivos Brasileiros de Endocrinologia & Metabologia, August 2006
DOI 10.1590/s0004-27302006000400008
Pubmed ID
Authors

Lília D'Souza-Li

Abstract

The calcium-sensing receptor (CASR) adjusts the extracellular calcium set point regulating PTH secretion and renal calcium excretion. The receptor is expressed in several tissues and is also involved in other cellular functions such as proliferation, differentiation and other hormonal secretion. High extracellular calcium levels activate the receptor resulting in modulation of several signaling pathways depending on the target tissues. Mutations in the CASR gene can result in gain or loss of receptor function. Gain of function mutations are associated to Autossomal dominant hypocalcemia and Bartter syndrome type V, while loss of function mutations are associated to Familial hypocalciuric hypercalcemia and Neonatal severe hyperparathyroidism. More than one hundred mutations were described in this gene. In addition to calcium, the receptor also interacts with several ions and polyamines. The CASR is a potential therapeutic target to treatment of diseases including hyperparathyroidism and osteoporosis, since its interaction with pharmacological compounds results in modulation of PTH secretion.

Mendeley readers

The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 3%
Unknown 32 97%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 10 30%
Student > Ph. D. Student 8 24%
Student > Master 5 15%
Professor > Associate Professor 3 9%
Professor 2 6%
Other 3 9%
Unknown 2 6%
Readers by discipline Count As %
Medicine and Dentistry 14 42%
Agricultural and Biological Sciences 8 24%
Biochemistry, Genetics and Molecular Biology 3 9%
Pharmacology, Toxicology and Pharmaceutical Science 2 6%
Veterinary Science and Veterinary Medicine 1 3%
Other 3 9%
Unknown 2 6%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 March 2022.
All research outputs
#4,334,769
of 21,370,427 outputs
Outputs from Arquivos Brasileiros de Endocrinologia & Metabologia
#39
of 470 outputs
Outputs of similar age
#64,055
of 323,938 outputs
Outputs of similar age from Arquivos Brasileiros de Endocrinologia & Metabologia
#1
of 1 outputs
Altmetric has tracked 21,370,427 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 470 research outputs from this source. They receive a mean Attention Score of 3.0. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 323,938 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them