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Minoxidil improves vascular compliance, restores cerebral blood flow, and alters extracellular matrix gene expression in a model of chronic vascular stiffness

Overview of attention for article published in American Journal of Physiology: Heart & Circulatory Physiology, July 2018
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#11 of 2,887)
  • High Attention Score compared to outputs of the same age (96th percentile)
  • High Attention Score compared to outputs of the same age and source (98th percentile)

Mentioned by

news
11 news outlets
blogs
1 blog
twitter
10 tweeters
reddit
1 Redditor

Citations

dimensions_citation
11 Dimensions

Readers on

mendeley
13 Mendeley
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Title
Minoxidil improves vascular compliance, restores cerebral blood flow, and alters extracellular matrix gene expression in a model of chronic vascular stiffness
Published in
American Journal of Physiology: Heart & Circulatory Physiology, July 2018
DOI 10.1152/ajpheart.00683.2017
Pubmed ID
Authors

Russell H. Knutsen, Scott C. Beeman, Thomas J. Broekelmann, Delong Liu, Kit Man Tsang, Attila Kovacs, Li Ye, Joshua R. Danback, Anderson Watson, Amanda Wardlaw, Jessica E. Wagenseil, Joel R. Garbow, Michael Shoykhet, Beth A. Kozel

Abstract

Increased vascular stiffness correlates with higher risk of cardiovascular complications in aging adults. Elastin insufficiency, as observed in patients with Williams-Beuren syndrome or with familial supravalvular aortic stenosis, also increases vascular stiffness and leads to arterial narrowing. We used Eln+/-mice to test the hypothesis that pathologically increased vascular stiffness with concomitant arterial narrowing leads to decreased blood flow to end organs such as the brain. We also hypothesized that drugs which remodel arteries and increase lumen diameter would improve flow. To test these hypotheses, we compared carotid blood flow using ultrasound and cerebral blood flow using MRI-based arterial spin labeling in WT and Eln+/-mice. We then studied how minoxidil, a KATPchannel opener and vasodilator, affects vessel mechanics, blood flow and gene expression. Both carotid and cerebral blood flows were lower in Eln+/-than in WT mice. Treatment of Eln+/-mice with minoxidil lowered blood pressure and reduced functional arterial stiffness to WT levels. Minoxidil also improved arterial diameter and restored carotid and cerebral blood flows in Eln+/-mice. Beneficial effects persisted for weeks after drug removal. RNA-Seq analysis revealed differential expression of 127 extracellular matrix-related genes among the treatment groups. These results indicate that elastin insufficiency impairs end organ perfusion, which may contribute to increased cardiovascular risk. Minoxidil, despite lowering blood pressure, improves end organ perfusion. Changes in matrix gene expression and persistence of treatment effects after drug withdrawal suggest arterial remodeling. Such remodeling may benefit patients with genetic or age-dependent elastin insufficiency.

Twitter Demographics

The data shown below were collected from the profiles of 10 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 13 100%

Demographic breakdown

Readers by professional status Count As %
Other 4 31%
Student > Ph. D. Student 3 23%
Student > Doctoral Student 1 8%
Student > Master 1 8%
Unknown 4 31%
Readers by discipline Count As %
Medicine and Dentistry 4 31%
Biochemistry, Genetics and Molecular Biology 2 15%
Agricultural and Biological Sciences 1 8%
Nursing and Health Professions 1 8%
Engineering 1 8%
Other 0 0%
Unknown 4 31%

Attention Score in Context

This research output has an Altmetric Attention Score of 91. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 August 2018.
All research outputs
#207,631
of 14,566,221 outputs
Outputs from American Journal of Physiology: Heart & Circulatory Physiology
#11
of 2,887 outputs
Outputs of similar age
#8,480
of 275,301 outputs
Outputs of similar age from American Journal of Physiology: Heart & Circulatory Physiology
#1
of 51 outputs
Altmetric has tracked 14,566,221 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,887 research outputs from this source. They receive a mean Attention Score of 4.1. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 275,301 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 51 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.