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Rac and Rho GTPases in cancer cell motility control

Overview of attention for article published in Cell Communication and Signaling, September 2010
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (86th percentile)

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1 X user
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6 patents
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2 Wikipedia pages

Citations

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493 Dimensions

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801 Mendeley
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Title
Rac and Rho GTPases in cancer cell motility control
Published in
Cell Communication and Signaling, September 2010
DOI 10.1186/1478-811x-8-23
Pubmed ID
Authors

Matteo Parri, Paola Chiarugi

Abstract

Rho GTPases represent a family of small GTP-binding proteins involved in cell cytoskeleton organization, migration, transcription, and proliferation. A common theme of these processes is a dynamic reorganization of actin cytoskeleton which has now emerged as a major switch control mainly carried out by Rho and Rac GTPase subfamilies, playing an acknowledged role in adaptation of cell motility to the microenvironment. Cells exhibit three distinct modes of migration when invading the 3 D environment. Collective motility leads to movement of cohorts of cells which maintain the adherens junctions and move by photolytic degradation of matrix barriers. Single cell mesenchymal-type movement is characterized by an elongated cellular shape and again requires extracellular proteolysis and integrin engagement. In addition it depends on Rac1-mediated cell polarization and lamellipodia formation. Conversely, in amoeboid movement cells have a rounded morphology, the movement is independent from proteases but requires high Rho GTPase to drive elevated levels of actomyosin contractility. These two modes of cell movement are interconvertible and several moving cells, including tumor cells, show an high degree of plasticity in motility styles shifting ad hoc between mesenchymal or amoeboid movements. This review will focus on the role of Rac and Rho small GTPases in cell motility and in the complex relationship driving the reciprocal control between Rac and Rho granting for the opportunistic motile behaviour of aggressive cancer cells. In addition we analyse the role of these GTPases in cancer progression and metastatic dissemination.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 801 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 6 <1%
United States 3 <1%
France 3 <1%
Portugal 1 <1%
Chile 1 <1%
Netherlands 1 <1%
Kazakhstan 1 <1%
Hong Kong 1 <1%
Germany 1 <1%
Other 8 <1%
Unknown 775 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 233 29%
Student > Master 109 14%
Researcher 107 13%
Student > Bachelor 88 11%
Student > Doctoral Student 42 5%
Other 105 13%
Unknown 117 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 284 35%
Biochemistry, Genetics and Molecular Biology 192 24%
Medicine and Dentistry 61 8%
Engineering 41 5%
Physics and Astronomy 21 3%
Other 72 9%
Unknown 130 16%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 March 2024.
All research outputs
#3,647,524
of 25,508,813 outputs
Outputs from Cell Communication and Signaling
#104
of 1,524 outputs
Outputs of similar age
#14,504
of 105,072 outputs
Outputs of similar age from Cell Communication and Signaling
#2
of 3 outputs
Altmetric has tracked 25,508,813 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,524 research outputs from this source. They receive a mean Attention Score of 3.8. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 105,072 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one.