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Rac and Rho GTPases in cancer cell motility control

Overview of attention for article published in Cell Communication and Signaling, September 2010
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About this Attention Score

  • Among the highest-scoring outputs from this source (#23 of 117)
  • Good Attention Score compared to outputs of the same age (67th percentile)

Mentioned by

1 Wikipedia page


341 Dimensions

Readers on

579 Mendeley
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Rac and Rho GTPases in cancer cell motility control
Published in
Cell Communication and Signaling, September 2010
DOI 10.1186/1478-811x-8-23
Pubmed ID

Matteo Parri, Paola Chiarugi


Rho GTPases represent a family of small GTP-binding proteins involved in cell cytoskeleton organization, migration, transcription, and proliferation. A common theme of these processes is a dynamic reorganization of actin cytoskeleton which has now emerged as a major switch control mainly carried out by Rho and Rac GTPase subfamilies, playing an acknowledged role in adaptation of cell motility to the microenvironment. Cells exhibit three distinct modes of migration when invading the 3 D environment. Collective motility leads to movement of cohorts of cells which maintain the adherens junctions and move by photolytic degradation of matrix barriers. Single cell mesenchymal-type movement is characterized by an elongated cellular shape and again requires extracellular proteolysis and integrin engagement. In addition it depends on Rac1-mediated cell polarization and lamellipodia formation. Conversely, in amoeboid movement cells have a rounded morphology, the movement is independent from proteases but requires high Rho GTPase to drive elevated levels of actomyosin contractility. These two modes of cell movement are interconvertible and several moving cells, including tumor cells, show an high degree of plasticity in motility styles shifting ad hoc between mesenchymal or amoeboid movements. This review will focus on the role of Rac and Rho small GTPases in cell motility and in the complex relationship driving the reciprocal control between Rac and Rho granting for the opportunistic motile behaviour of aggressive cancer cells. In addition we analyse the role of these GTPases in cancer progression and metastatic dissemination.

Mendeley readers

The data shown below were compiled from readership statistics for 579 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 6 1%
United States 3 <1%
France 3 <1%
Germany 2 <1%
South Africa 1 <1%
Netherlands 1 <1%
Kazakhstan 1 <1%
Hong Kong 1 <1%
Chile 1 <1%
Other 8 1%
Unknown 552 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 186 32%
Researcher 89 15%
Student > Master 87 15%
Student > Bachelor 70 12%
Student > Doctoral Student 32 6%
Other 84 15%
Unknown 31 5%
Readers by discipline Count As %
Agricultural and Biological Sciences 273 47%
Biochemistry, Genetics and Molecular Biology 119 21%
Medicine and Dentistry 58 10%
Engineering 32 6%
Physics and Astronomy 14 2%
Other 45 8%
Unknown 38 7%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 August 2014.
All research outputs
of 4,156,414 outputs
Outputs from Cell Communication and Signaling
of 117 outputs
Outputs of similar age
of 135,050 outputs
Outputs of similar age from Cell Communication and Signaling
of 4 outputs
Altmetric has tracked 4,156,414 research outputs across all sources so far. This one has received more attention than most of these and is in the 63rd percentile.
So far Altmetric has tracked 117 research outputs from this source. They receive a mean Attention Score of 2.9. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 135,050 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them