↓ Skip to main content

Rac and Rho GTPases in cancer cell motility control

Overview of attention for article published in Cell Communication and Signaling, September 2010
Altmetric Badge

About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#41 of 520)
  • Good Attention Score compared to outputs of the same age (79th percentile)
  • High Attention Score compared to outputs of the same age and source (88th percentile)

Mentioned by

1 patent
1 Wikipedia page


371 Dimensions

Readers on

619 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Rac and Rho GTPases in cancer cell motility control
Published in
Cell Communication and Signaling, September 2010
DOI 10.1186/1478-811x-8-23
Pubmed ID

Matteo Parri, Paola Chiarugi


Rho GTPases represent a family of small GTP-binding proteins involved in cell cytoskeleton organization, migration, transcription, and proliferation. A common theme of these processes is a dynamic reorganization of actin cytoskeleton which has now emerged as a major switch control mainly carried out by Rho and Rac GTPase subfamilies, playing an acknowledged role in adaptation of cell motility to the microenvironment. Cells exhibit three distinct modes of migration when invading the 3 D environment. Collective motility leads to movement of cohorts of cells which maintain the adherens junctions and move by photolytic degradation of matrix barriers. Single cell mesenchymal-type movement is characterized by an elongated cellular shape and again requires extracellular proteolysis and integrin engagement. In addition it depends on Rac1-mediated cell polarization and lamellipodia formation. Conversely, in amoeboid movement cells have a rounded morphology, the movement is independent from proteases but requires high Rho GTPase to drive elevated levels of actomyosin contractility. These two modes of cell movement are interconvertible and several moving cells, including tumor cells, show an high degree of plasticity in motility styles shifting ad hoc between mesenchymal or amoeboid movements. This review will focus on the role of Rac and Rho small GTPases in cell motility and in the complex relationship driving the reciprocal control between Rac and Rho granting for the opportunistic motile behaviour of aggressive cancer cells. In addition we analyse the role of these GTPases in cancer progression and metastatic dissemination.

Mendeley readers

The data shown below were compiled from readership statistics for 619 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 6 <1%
United States 3 <1%
France 3 <1%
Germany 2 <1%
South Africa 1 <1%
Netherlands 1 <1%
Kazakhstan 1 <1%
Hong Kong 1 <1%
Chile 1 <1%
Other 8 1%
Unknown 592 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 195 32%
Student > Master 98 16%
Researcher 92 15%
Student > Bachelor 70 11%
Student > Doctoral Student 34 5%
Other 85 14%
Unknown 45 7%
Readers by discipline Count As %
Agricultural and Biological Sciences 279 45%
Biochemistry, Genetics and Molecular Biology 130 21%
Medicine and Dentistry 58 9%
Engineering 35 6%
Physics and Astronomy 14 2%
Other 48 8%
Unknown 55 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 December 2018.
All research outputs
of 14,807,872 outputs
Outputs from Cell Communication and Signaling
of 520 outputs
Outputs of similar age
of 284,329 outputs
Outputs of similar age from Cell Communication and Signaling
of 9 outputs
Altmetric has tracked 14,807,872 research outputs across all sources so far. Compared to these this one has done well and is in the 77th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 520 research outputs from this source. They receive a mean Attention Score of 2.7. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 284,329 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them