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Phosphoinositides I: Enzymes of Synthesis and Degradation

Overview of attention for book
Attention for Chapter 2: PIP Kinases from the Cell Membrane to the Nucleus.
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Chapter title
PIP Kinases from the Cell Membrane to the Nucleus.
Chapter number 2
Book title
Phosphoinositides I: Enzymes of Synthesis and Degradation
Published in
Sub cellular biochemistry, March 2012
DOI 10.1007/978-94-007-3012-0_2
Pubmed ID
Book ISBNs
978-9-40-073011-3, 978-9-40-073012-0
Authors

Schramp M, Hedman A, Li W, Tan X, Anderson R, Mark Schramp, Andrew Hedman, Weimin Li, Xiaojun Tan, Richard Anderson

Abstract

Phosphatidylinositol 4,5-bisphosphate (PIP(2)) is a membrane bound lipid molecule with capabilities to affect a wide array of signaling pathways to regulate very different cellular processes. PIP(2) is used as a precursor to generate the second messengers PIP(3), DAG and IP(3), indispensable molecules for signaling events generated by membrane receptors. However, PIP(2) can also directly regulate a vast array of proteins and is emerging as a crucial messenger with the potential to distinctly modulate biological processes critical for both normal and pathogenic cell physiology. PIP(2) directly associates with effector proteins via unique phosphoinositide binding domains, altering their localization and/or enzymatic activity. The spatial and temporal generation of PIP(2) synthesized by the phosphatidylinositol phosphate kinases (PIPKs) tightly regulates the activation of receptor signaling pathways, endocytosis and vesicle trafficking, cell polarity, focal adhesion dynamics, actin assembly and 3' mRNA processing. Here we discuss our current understanding of PIPKs in the regulation of cellular processes from the plasma membrane to the nucleus.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Unknown 41 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 26%
Researcher 11 26%
Professor > Associate Professor 7 17%
Student > Bachelor 4 10%
Student > Doctoral Student 3 7%
Other 5 12%
Unknown 1 2%
Readers by discipline Count As %
Agricultural and Biological Sciences 19 45%
Biochemistry, Genetics and Molecular Biology 8 19%
Medicine and Dentistry 4 10%
Neuroscience 2 5%
Physics and Astronomy 2 5%
Other 4 10%
Unknown 3 7%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 March 2012.
All research outputs
#5,597,027
of 6,560,926 outputs
Outputs from Sub cellular biochemistry
#146
of 187 outputs
Outputs of similar age
#68,439
of 83,702 outputs
Outputs of similar age from Sub cellular biochemistry
#12
of 13 outputs
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So far Altmetric has tracked 187 research outputs from this source. They receive a mean Attention Score of 1.9. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.