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SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27.

Overview of attention for article published in Nature Cell Biology, August 1999
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (72nd percentile)

Mentioned by

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1 Wikipedia page

Citations

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1170 Dimensions

Readers on

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215 Mendeley
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1 CiteULike
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Title
SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27.
Published in
Nature Cell Biology, August 1999
Pubmed ID
Authors

A C Carrano, E Eytan, A Hershko, M Pagano

Abstract

Degradation of the mammalian cyclin-dependent kinase (CDK) inhibitor p27 is required for the cellular transition from quiescence to the proliferative state. The ubiquitination and subsequent degradation of p27 depend on its phosphorylation by cyclin-CDK complexes. However, the ubiquitin-protein ligase necessary for p27 ubiquitination has not been identified. Here we show that the F-box protein SKP2 specifically recognizes p27 in a phosphorylation-dependent manner that is characteristic of an F-box-protein-substrate interaction. Furthermore, both in vivo and in vitro, SKP2 is a rate-limiting component of the machinery that ubiquitinates and degrades phosphorylated p27. Thus, p27 degradation is subject to dual control by the accumulation of both SKP2 and cyclins following mitogenic stimulation.

Mendeley readers

The data shown below were compiled from readership statistics for 215 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 2%
Germany 2 <1%
Spain 2 <1%
Iceland 1 <1%
Switzerland 1 <1%
Italy 1 <1%
United Kingdom 1 <1%
Unknown 203 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 68 32%
Researcher 30 14%
Student > Bachelor 22 10%
Student > Master 18 8%
Student > Doctoral Student 18 8%
Other 37 17%
Unknown 22 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 97 45%
Biochemistry, Genetics and Molecular Biology 45 21%
Medicine and Dentistry 24 11%
Chemistry 9 4%
Neuroscience 4 2%
Other 8 4%
Unknown 28 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 May 2009.
All research outputs
#815,880
of 3,633,425 outputs
Outputs from Nature Cell Biology
#723
of 1,989 outputs
Outputs of similar age
#25,069
of 96,036 outputs
Outputs of similar age from Nature Cell Biology
#50
of 52 outputs
Altmetric has tracked 3,633,425 research outputs across all sources so far. This one has received more attention than most of these and is in the 63rd percentile.
So far Altmetric has tracked 1,989 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has gotten more attention than average, scoring higher than 52% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 96,036 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 52 others from the same source and published within six weeks on either side of this one. This one is in the 3rd percentile – i.e., 3% of its contemporaries scored the same or lower than it.