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Secreted Immunomodulatory Proteins of Staphylococcus aureus Activate Platelets and Induce Platelet Aggregation

Overview of attention for article published in Thrombosis and Haemostasis, March 2018
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  • Above-average Attention Score compared to outputs of the same age and source (51st percentile)

Mentioned by

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4 tweeters

Citations

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11 Dimensions

Readers on

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22 Mendeley
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Title
Secreted Immunomodulatory Proteins of Staphylococcus aureus Activate Platelets and Induce Platelet Aggregation
Published in
Thrombosis and Haemostasis, March 2018
DOI 10.1055/s-0038-1637735
Pubmed ID
Authors

Ulrike Binsker, Raghavendra Palankar, Jan Wesche, Thomas Kohler, Josephine Prucha, Gerhard Burchhardt, Manfred Rohde, Frank Schmidt, Barbara Bröker, Uwe Mamat, Jan Pané-Farré, Anica Graf, Patrick Ebner, Andreas Greinacher, Sven Hammerschmidt

Abstract

Staphylococcus aureus can cause bloodstream infections associated with infective endocarditis (IE) and disseminated intravascular coagulopathy (DIC). Both complications involve platelets. In view of an increasing number of antibiotic-resistant strains, new approaches to control systemic S. aureus infection are gaining importance. Using a repertoire of 52 recombinant S. aureus proteins in flow cytometry-based platelet activation and aggregation assays, we identified, in addition to the extracellular adherence protein Eap, three secreted staphylococcal proteins as novel platelet activating proteins. Eap and the chemotaxis inhibitory protein of S. aureus (CHIPS), the formyl peptide receptor-like 1 inhibitory protein (FLIPr) and the major autolysin Atl induced P-selectin expression in washed platelets and platelet-rich plasma. Similarly, AtlA, CHIPS and Eap induced platelet aggregation in whole blood. Fluorescence microscopy illustrated that P-selectin expression is associated with calcium mobilization and re-organization of the platelet actin cytoskeleton. Characterization of the functionally active domains of the major autolysin AtlA and Eap indicates that the amidase domain of Atl and the tandem repeats 3 and 4 of Eap are crucial for platelet activation. These results provide new insights in S. aureus protein interactions with platelets and identify secreted proteins as potential treatment targets in case of antibiotic-resistant S. aureus infection.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 22 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 23%
Student > Bachelor 3 14%
Student > Master 2 9%
Student > Postgraduate 2 9%
Student > Ph. D. Student 2 9%
Other 5 23%
Unknown 3 14%
Readers by discipline Count As %
Immunology and Microbiology 6 27%
Biochemistry, Genetics and Molecular Biology 3 14%
Medicine and Dentistry 3 14%
Agricultural and Biological Sciences 2 9%
Unspecified 1 5%
Other 2 9%
Unknown 5 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 March 2018.
All research outputs
#7,922,105
of 14,100,448 outputs
Outputs from Thrombosis and Haemostasis
#1,807
of 2,548 outputs
Outputs of similar age
#136,389
of 277,104 outputs
Outputs of similar age from Thrombosis and Haemostasis
#21
of 43 outputs
Altmetric has tracked 14,100,448 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,548 research outputs from this source. They receive a mean Attention Score of 3.8. This one is in the 28th percentile – i.e., 28% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 277,104 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 43 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.