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Microbiome–host systems interactions: protective effects of propionate upon the blood–brain barrier

Overview of attention for article published in Microbiome, March 2018
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (95th percentile)
  • High Attention Score compared to outputs of the same age and source (84th percentile)

Mentioned by

blogs
1 blog
twitter
100 X users
facebook
1 Facebook page
wikipedia
2 Wikipedia pages
reddit
2 Redditors

Citations

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337 Dimensions

Readers on

mendeley
393 Mendeley
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Title
Microbiome–host systems interactions: protective effects of propionate upon the blood–brain barrier
Published in
Microbiome, March 2018
DOI 10.1186/s40168-018-0439-y
Pubmed ID
Authors

Lesley Hoyles, Tom Snelling, Umm-Kulthum Umlai, Jeremy K. Nicholson, Simon R. Carding, Robert C. Glen, Simon McArthur

Abstract

Gut microbiota composition and function are symbiotically linked with host health and altered in metabolic, inflammatory and neurodegenerative disorders. Three recognised mechanisms exist by which the microbiome influences the gut-brain axis: modification of autonomic/sensorimotor connections, immune activation, and neuroendocrine pathway regulation. We hypothesised interactions between circulating gut-derived microbial metabolites, and the blood-brain barrier (BBB) also contribute to the gut-brain axis. Propionate, produced from dietary substrates by colonic bacteria, stimulates intestinal gluconeogenesis and is associated with reduced stress behaviours, but its potential endocrine role has not been addressed. After demonstrating expression of the propionate receptor FFAR3 on human brain endothelium, we examined the impact of a physiologically relevant propionate concentration (1 μM) on BBB properties in vitro. Propionate inhibited pathways associated with non-specific microbial infections via a CD14-dependent mechanism, suppressed expression of LRP-1 and protected the BBB from oxidative stress via NRF2 (NFE2L2) signalling. Together, these results suggest gut-derived microbial metabolites interact with the BBB, representing a fourth facet of the gut-brain axis that warrants further attention.

X Demographics

X Demographics

The data shown below were collected from the profiles of 100 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 393 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 393 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 54 14%
Student > Ph. D. Student 50 13%
Student > Master 39 10%
Student > Bachelor 38 10%
Other 21 5%
Other 63 16%
Unknown 128 33%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 60 15%
Agricultural and Biological Sciences 41 10%
Neuroscience 37 9%
Medicine and Dentistry 30 8%
Immunology and Microbiology 26 7%
Other 50 13%
Unknown 149 38%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 63. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 December 2023.
All research outputs
#683,364
of 25,530,891 outputs
Outputs from Microbiome
#185
of 1,776 outputs
Outputs of similar age
#15,565
of 348,004 outputs
Outputs of similar age from Microbiome
#10
of 58 outputs
Altmetric has tracked 25,530,891 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,776 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 38.0. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 348,004 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 58 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.